Coating of carboxymethyl dextran on liposomal curcumin to improve the anticancer activity

Qiyu Huang; Lili Zhang; Xiaoyi Sun; Ke Zeng; Juan Li; You Nian Liu

doi:10.1039/c4ra11181h

Coating of carboxymethyl dextran on liposomal curcumin to improve the anticancer activity

Qiyu Huang, Lili Zhang, Xiaoyi Sun, Ke Zeng, Juan Li^*, You Nian Liu

^*Corresponding author for this work

Central South University

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

In this work, carboxymethyl dextran (CMD), a polysaccharidic dextran derivative with well-known biocompatibility and biodegradability, was used to modify curcumin-loaded liposomes for improving the anticancer efficacy of curcumin. The CMDylated curcumin-loaded liposomes (CMD-Cur-Lip) were successfully prepared and characterized in comparison with unmodified and two PEGylated curcumin-loaded liposomes. The results showed that: (1) the encapsulation efficiency of curcumin in the liposomes was improved after being modified with CMD; (2) all the curcumin-loaded liposomes displayed controlled release characteristics; (3) the CMD-Cur-Lip demonstrated improved cell cytotoxicity against cancer cells, as compared to other liposomal formulations and free curcumin; (4) CMD-Cur-Lip exhibited the highest cellular uptake as compared to other liposomal formulations.

Original language	English
Pages (from-to)	59211-59217
Number of pages	7
Journal	RSC Advances
Volume	4
Issue number	103
DOIs	https://doi.org/10.1039/c4ra11181h
Publication status	Published - 28 Oct 2014
Externally published	Yes

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title = "Coating of carboxymethyl dextran on liposomal curcumin to improve the anticancer activity",

abstract = "In this work, carboxymethyl dextran (CMD), a polysaccharidic dextran derivative with well-known biocompatibility and biodegradability, was used to modify curcumin-loaded liposomes for improving the anticancer efficacy of curcumin. The CMDylated curcumin-loaded liposomes (CMD-Cur-Lip) were successfully prepared and characterized in comparison with unmodified and two PEGylated curcumin-loaded liposomes. The results showed that: (1) the encapsulation efficiency of curcumin in the liposomes was improved after being modified with CMD; (2) all the curcumin-loaded liposomes displayed controlled release characteristics; (3) the CMD-Cur-Lip demonstrated improved cell cytotoxicity against cancer cells, as compared to other liposomal formulations and free curcumin; (4) CMD-Cur-Lip exhibited the highest cellular uptake as compared to other liposomal formulations.",

author = "Qiyu Huang and Lili Zhang and Xiaoyi Sun and Ke Zeng and Juan Li and Liu, {You Nian}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2014.",

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doi = "10.1039/c4ra11181h",

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T1 - Coating of carboxymethyl dextran on liposomal curcumin to improve the anticancer activity

AU - Huang, Qiyu

AU - Zhang, Lili

AU - Sun, Xiaoyi

AU - Zeng, Ke

AU - Li, Juan

AU - Liu, You Nian

PY - 2014/10/28

Y1 - 2014/10/28

N2 - In this work, carboxymethyl dextran (CMD), a polysaccharidic dextran derivative with well-known biocompatibility and biodegradability, was used to modify curcumin-loaded liposomes for improving the anticancer efficacy of curcumin. The CMDylated curcumin-loaded liposomes (CMD-Cur-Lip) were successfully prepared and characterized in comparison with unmodified and two PEGylated curcumin-loaded liposomes. The results showed that: (1) the encapsulation efficiency of curcumin in the liposomes was improved after being modified with CMD; (2) all the curcumin-loaded liposomes displayed controlled release characteristics; (3) the CMD-Cur-Lip demonstrated improved cell cytotoxicity against cancer cells, as compared to other liposomal formulations and free curcumin; (4) CMD-Cur-Lip exhibited the highest cellular uptake as compared to other liposomal formulations.

AB - In this work, carboxymethyl dextran (CMD), a polysaccharidic dextran derivative with well-known biocompatibility and biodegradability, was used to modify curcumin-loaded liposomes for improving the anticancer efficacy of curcumin. The CMDylated curcumin-loaded liposomes (CMD-Cur-Lip) were successfully prepared and characterized in comparison with unmodified and two PEGylated curcumin-loaded liposomes. The results showed that: (1) the encapsulation efficiency of curcumin in the liposomes was improved after being modified with CMD; (2) all the curcumin-loaded liposomes displayed controlled release characteristics; (3) the CMD-Cur-Lip demonstrated improved cell cytotoxicity against cancer cells, as compared to other liposomal formulations and free curcumin; (4) CMD-Cur-Lip exhibited the highest cellular uptake as compared to other liposomal formulations.

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Coating of carboxymethyl dextran on liposomal curcumin to improve the anticancer activity

Abstract

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