Chiral iridium catalysts bearing spiro pyridine-aminophosphine ligands enable highly efficient asymmetric hydrogenation of β-aryl β-ketoesters

Jian Hua Xie; Xiao Yan Liu; Xiao Hui Yang; Jian Bo Xie; Li Xin Wang; Qi Lin Zhou

doi:10.1002/anie.201105780

Chiral iridium catalysts bearing spiro pyridine-aminophosphine ligands enable highly efficient asymmetric hydrogenation of β-aryl β-ketoesters

Jian Hua Xie^*
, Xiao Yan Liu
, Xiao Hui Yang
, Jian Bo Xie
, Li Xin Wang
, Qi Lin Zhou

^*Corresponding author for this work

Nankai University

Research output: Contribution to journal › Article › peer-review

138 Citations (Scopus)

Abstract

Tons of TONs: Chiral iridium catalysts bearing ligand 1 are highly efficient for the asymmetric hydrogenation of β-substituted β-ketoesters. The product β-hydroxyesters are delivered in high yield with excellent enantioselectivities and high turnover numbers (TONs). cod= 1,5-cyclooctadiene.

Original language	English
Pages (from-to)	201-203
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	1
DOIs	https://doi.org/10.1002/anie.201105780
Publication status	Published - 2 Jan 2012
Externally published	Yes

Keywords

enantioselectivity
hydrogenation
iridium
ligand effects
synthetic methods

Access to Document

10.1002/anie.201105780

Cite this

@article{c1f494f9590e40448ba75399b6428023,

title = "Chiral iridium catalysts bearing spiro pyridine-aminophosphine ligands enable highly efficient asymmetric hydrogenation of β-aryl β-ketoesters",

abstract = "Tons of TONs: Chiral iridium catalysts bearing ligand 1 are highly efficient for the asymmetric hydrogenation of β-substituted β-ketoesters. The product β-hydroxyesters are delivered in high yield with excellent enantioselectivities and high turnover numbers (TONs). cod= 1,5-cyclooctadiene.",

keywords = "enantioselectivity, hydrogenation, iridium, ligand effects, synthetic methods",

author = "Xie, \{Jian Hua\} and Liu, \{Xiao Yan\} and Yang, \{Xiao Hui\} and Xie, \{Jian Bo\} and Wang, \{Li Xin\} and Zhou, \{Qi Lin\}",

year = "2012",

month = jan,

day = "2",

doi = "10.1002/anie.201105780",

language = "English",

volume = "51",

pages = "201--203",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "1",

}

TY - JOUR

T1 - Chiral iridium catalysts bearing spiro pyridine-aminophosphine ligands enable highly efficient asymmetric hydrogenation of β-aryl β-ketoesters

AU - Xie, Jian Hua

AU - Liu, Xiao Yan

AU - Yang, Xiao Hui

AU - Xie, Jian Bo

AU - Wang, Li Xin

AU - Zhou, Qi Lin

PY - 2012/1/2

Y1 - 2012/1/2

N2 - Tons of TONs: Chiral iridium catalysts bearing ligand 1 are highly efficient for the asymmetric hydrogenation of β-substituted β-ketoesters. The product β-hydroxyesters are delivered in high yield with excellent enantioselectivities and high turnover numbers (TONs). cod= 1,5-cyclooctadiene.

AB - Tons of TONs: Chiral iridium catalysts bearing ligand 1 are highly efficient for the asymmetric hydrogenation of β-substituted β-ketoesters. The product β-hydroxyesters are delivered in high yield with excellent enantioselectivities and high turnover numbers (TONs). cod= 1,5-cyclooctadiene.

KW - enantioselectivity

KW - hydrogenation

KW - iridium

KW - ligand effects

KW - synthetic methods

UR - https://www.scopus.com/pages/publications/84855264047

U2 - 10.1002/anie.201105780

DO - 10.1002/anie.201105780

M3 - Article

C2 - 22095722

AN - SCOPUS:84855264047

SN - 1433-7851

VL - 51

SP - 201

EP - 203

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 1

ER -

Chiral iridium catalysts bearing spiro pyridine-aminophosphine ligands enable highly efficient asymmetric hydrogenation of β-aryl β-ketoesters

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this