Cell manipulation and cellular parts assembly for constructing 3D cellular systems

Masaru Kojima, Yasushi Mae, Kenichi Ohara, Mitsuhiro Horade, Kazuto Kamiyama, Tatsuo Arai*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Bio Assembler integrates the state-of-the-art micro robotics and tissue engineering to create 3D tissues in vitro. In Bio Assembler we have different key technologies in different complex structure for creating 3D cellular systems. In this chapter, we have reviewed our recent progress to construct 3D cellular systems. Especially, introduce three key technologies of micro robotics for 3D cellular construction, (1) Cell manipulation by microhand, (2) Construction of 3D lattice by hydrogel fiber and (3) Changeable Cell Culture mold for Advanced Cell Sheet. These proposed new technologies contribute to realize “Bio Assembler”.

Original languageEnglish
Title of host publicationHyper Bio Assembler for 3D Cellular Systems
PublisherSpringer Japan
Pages93-128
Number of pages36
ISBN (Electronic)9784431552970
ISBN (Print)9784431552963
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Keywords

  • Alginate gel fiber
  • Cell culture device
  • Microactuator array
  • Micromanipulation
  • Multi-scalability
  • Parallel link mechanism

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