Abstract
The enantioselective tandem Friedel-Crafts alkylation/Michael addition reaction of indoles with nitroolefin enoates catalyzed by a diphenylamine-linked bis(oxazoline)-Zn(OTf)2 complex was investigated. This tandem reaction afforded functionalized chiral chromans in good yields with moderate to high stereoselectivities (up to 95:5 dr, up to 99% ee).
Original language | English |
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Pages (from-to) | 1210-1216 |
Number of pages | 7 |
Journal | Beilstein Journal of Organic Chemistry |
Volume | 9 |
DOIs | |
Publication status | Published - 24 Jun 2013 |
Keywords
- Asymmetric catalysis
- Bis(oxazoline)
- Chroman
- Friedel-Crafts alkylation
- Tandem reaction