Bioprofiling and vaccine development for Zika virus

Huiping Shi; Shengyong Feng; Abid Naeem; Baoying Huang; Wenjie Tan; Lulu Zheng; Xing Jie Liang; Minghui Yang; Yuanyu Huang

doi:10.1007/s11427-024-2851-4

Bioprofiling and vaccine development for Zika virus

Huiping Shi, Shengyong Feng, Abid Naeem, Baoying Huang, Wenjie Tan, Lulu Zheng, Xing Jie Liang, Minghui Yang^*, Yuanyu Huang^*

^*Corresponding author for this work

School of Life Science

Research output: Contribution to journal › Review article › peer-review

Abstract

Zika virus (ZIKV) has emerged as a global health priority due to its association with severe congenital abnormalities, including microcephaly and neonatal mortality in infants born to infected mothers. In adults, ZIKV infection is epidemiologically linked to Guillain-Barré Syndrome (GBS). These clinical manifestations prompted the World Health Organization (WHO) to declare ZIKV a Public Health Emergency of International Concern (PHEIC). The antibody-dependent enhancement (ADE) phenomenon further complicates vaccine development and therapeutic strategies. While substantial progress has been made in elucidating ZIKV biology through multidisciplinary approaches, no vaccines or therapies have been clinically approved. This review examines ZIKV-associated risks by analyzing transmission dynamics, viral architecture, and cellular entry mechanisms, and proposes evidence-based prevention and management strategies.

Original language	English
Journal	Science China Life Sciences
DOIs	https://doi.org/10.1007/s11427-024-2851-4
Publication status	Accepted/In press - 2025

Keywords

invasion mechanisms
transmission pathways
vaccines
viral structure
Zika virus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11427-024-2851-4

Cite this

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title = "Bioprofiling and vaccine development for Zika virus",

abstract = "Zika virus (ZIKV) has emerged as a global health priority due to its association with severe congenital abnormalities, including microcephaly and neonatal mortality in infants born to infected mothers. In adults, ZIKV infection is epidemiologically linked to Guillain-Barr{\'e} Syndrome (GBS). These clinical manifestations prompted the World Health Organization (WHO) to declare ZIKV a Public Health Emergency of International Concern (PHEIC). The antibody-dependent enhancement (ADE) phenomenon further complicates vaccine development and therapeutic strategies. While substantial progress has been made in elucidating ZIKV biology through multidisciplinary approaches, no vaccines or therapies have been clinically approved. This review examines ZIKV-associated risks by analyzing transmission dynamics, viral architecture, and cellular entry mechanisms, and proposes evidence-based prevention and management strategies.",

keywords = "invasion mechanisms, transmission pathways, vaccines, viral structure, Zika virus",

author = "Huiping Shi and Shengyong Feng and Abid Naeem and Baoying Huang and Wenjie Tan and Lulu Zheng and Liang, \{Xing Jie\} and Minghui Yang and Yuanyu Huang",

note = "Publisher Copyright: {\textcopyright} Science China Press 2025.",

year = "2025",

doi = "10.1007/s11427-024-2851-4",

language = "English",

journal = "Science China Life Sciences",

issn = "1674-7305",

publisher = "Science China Press",

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TY - JOUR

T1 - Bioprofiling and vaccine development for Zika virus

AU - Shi, Huiping

AU - Feng, Shengyong

AU - Naeem, Abid

AU - Huang, Baoying

AU - Tan, Wenjie

AU - Zheng, Lulu

AU - Liang, Xing Jie

AU - Yang, Minghui

AU - Huang, Yuanyu

PY - 2025

Y1 - 2025

N2 - Zika virus (ZIKV) has emerged as a global health priority due to its association with severe congenital abnormalities, including microcephaly and neonatal mortality in infants born to infected mothers. In adults, ZIKV infection is epidemiologically linked to Guillain-Barré Syndrome (GBS). These clinical manifestations prompted the World Health Organization (WHO) to declare ZIKV a Public Health Emergency of International Concern (PHEIC). The antibody-dependent enhancement (ADE) phenomenon further complicates vaccine development and therapeutic strategies. While substantial progress has been made in elucidating ZIKV biology through multidisciplinary approaches, no vaccines or therapies have been clinically approved. This review examines ZIKV-associated risks by analyzing transmission dynamics, viral architecture, and cellular entry mechanisms, and proposes evidence-based prevention and management strategies.

AB - Zika virus (ZIKV) has emerged as a global health priority due to its association with severe congenital abnormalities, including microcephaly and neonatal mortality in infants born to infected mothers. In adults, ZIKV infection is epidemiologically linked to Guillain-Barré Syndrome (GBS). These clinical manifestations prompted the World Health Organization (WHO) to declare ZIKV a Public Health Emergency of International Concern (PHEIC). The antibody-dependent enhancement (ADE) phenomenon further complicates vaccine development and therapeutic strategies. While substantial progress has been made in elucidating ZIKV biology through multidisciplinary approaches, no vaccines or therapies have been clinically approved. This review examines ZIKV-associated risks by analyzing transmission dynamics, viral architecture, and cellular entry mechanisms, and proposes evidence-based prevention and management strategies.

KW - invasion mechanisms

KW - transmission pathways

KW - vaccines

KW - viral structure

KW - Zika virus

UR - http://www.scopus.com/inward/record.url?scp=105007292108&partnerID=8YFLogxK

U2 - 10.1007/s11427-024-2851-4

DO - 10.1007/s11427-024-2851-4

M3 - Review article

AN - SCOPUS:105007292108

SN - 1674-7305

JO - Science China Life Sciences

JF - Science China Life Sciences

ER -

Bioprofiling and vaccine development for Zika virus

Abstract

Keywords

UN SDGs

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