Biomarkers of ageing of humans and non-human primates

Aging Biomarker Consortium

doi:10.1038/s41580-025-00883-8

Biomarkers of ageing of humans and non-human primates

Aging Biomarker Consortium

CAS - Institute of Zoology
Jilin University
Beijing Institute for Stem Cell and Regenerative Medicine
University of Chinese Academy of Sciences
Capital Medical University
CAS - Beijing Institute of Genomics
CAS - Center for Excellence in Molecular Cell Science
Ningxia Medical University
Army Medical University
The University of Hong Kong
Tsinghua University
Tongji Hospital Affiliated To Tongji University
East China University of Science and Technology
Shandong First Medical University & Shandong Academy of Medical Sciences
Shanghai Jiao Tong University
Tongji University
Naval Medical University
Central South University
Beijing Normal University
Xiamen University
Chinese Academy of Medical Sciences
Peking University
Beijing Hospital
Sun Yat-Sen University
General Hospital of People's Liberation Army
Nanfang Hospital
Huazhong University of Science and Technology
Air Force Medical University
Sichuan University
Chongqing University
Fudan University
Guangdong Provincial People’s Hospital of Southern Medical University
Shandong University
Shenzhen University of Advanced Technology
Shanghai University
Xijing Hospital
Beijing Institute of Technology
Southeast University, Nanjing
CAS - Shanghai Institute of Organic Chemistry
East China Normal University
University of Science and Technology of China
CAS - Shanghai Institute of Nutrition and Health
The First Affiliated Hospital of Chongqing Medical University
Southern University of Science and Technology
CAS - Shanghai Institute of Ceramics
Shanxi Medical University
Third Military Medical University
Tianjin First Central Hospital
Chinese University of Hong Kong
Anhui Medical University
China Medical University
CAS - Institute of Genetics and Developmental Biology
Nanchang University
The First Affiliated Hospital of Sun Yat-sen University
Academy of Military Medical Science China
Wenzhou Medical University
Chongqing Medical University
Hainan Medical University
Nanjing University
Wuhan University
CAS - Guangzhou Institute of Biomedicine and Health
Tianjin Medical University
CAS - Institute of Biophysics
Nankai University
Hangzhou Normal University
Shenzhen University
Frontier Institute of Science and Technology
The Third Affiliated Hospital of Sun Yat-sen University
The First Affiliated Hospital of Nanjing Medical University
CAS - Kunming Institute of Zoology
Jinan University
Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College
Guangzhou Laboratory
State Key Laboratory for Innovation and Transformation of Luobing Theory
Fujian Medical University
Zhongnan Hospital of Wuhan University
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College
Hong Kong Polytechnic University
China Pharmaceutical University
Dalian Medical University
The First Affiliated Hospital of University of Science and Technology of China
Gempharmatech Corp
Qilu Hospital of Shandong University
Sichuan University
West China Second University Hospital
Harbin Institute of Technology
National Clinical Research Center for Geriatric Diseases
Chinese Academy of Sciences

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

Ageing is characterized by progressive functional decline and increase in disease risk and imposes substantial burdens on human health. Identifying aging biomarkers in primates is crucial for advancing our understanding of human ageing and for informing interventions to mitigate age-related pathologies. However, a comprehensive grasp of these biomarkers is still lacking, hindering the translation of fundamental research into clinical practice. In this Review, we present the current knowledge on biomarkers of ageing at the cellular, tissue and organism levels in humans and non-human primates. Through systematic analysis of representative biomarkers across diverse biological contexts and scales, we discuss both the variability and the conservation of ageing-associated physiological changes, underscoring their importance in assessing and intervening in the ageing process. Finally, we critically assess challenges in ageing research and outline strategic avenues for future investigation.

Original language	English
Pages (from-to)	826-847
Number of pages	22
Journal	Nature Reviews Molecular Cell Biology
Volume	26
Issue number	11
DOIs	https://doi.org/10.1038/s41580-025-00883-8
Publication status	Published - Nov 2025
Externally published	Yes

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10.1038/s41580-025-00883-8

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@article{d9d98637f2fb43628ffa8503f4e9fe62,

title = "Biomarkers of ageing of humans and non-human primates",

abstract = "Ageing is characterized by progressive functional decline and increase in disease risk and imposes substantial burdens on human health. Identifying aging biomarkers in primates is crucial for advancing our understanding of human ageing and for informing interventions to mitigate age-related pathologies. However, a comprehensive grasp of these biomarkers is still lacking, hindering the translation of fundamental research into clinical practice. In this Review, we present the current knowledge on biomarkers of ageing at the cellular, tissue and organism levels in humans and non-human primates. Through systematic analysis of representative biomarkers across diverse biological contexts and scales, we discuss both the variability and the conservation of ageing-associated physiological changes, underscoring their importance in assessing and intervening in the ageing process. Finally, we critically assess challenges in ageing research and outline strategic avenues for future investigation.",

author = "\{Aging Biomarker Consortium\} and Zeming Wu and Jing Qu and Weiqi Zhang and Weiguo Zou and Wenjuan Zhuang and Zhiming Zhu and Zhongjun Zhou and Zhuozhao Zheng and Zheng, \{Jialin C.\} and Yuzheng Zhao and Tongbiao Zhao and Jiajun Zhao and Zhang, \{Zhen Lin\} and Xiaoqing Zhang and Zhang, \{Weiping J.\} and Zhuohua Zhang and Changqing Zhang and Zhanjun Zhang and Zhang, \{Yun Wu\} and Yong Zhang and Yan Zhang and Xuxiang Zhang and Xinchao Zhang and Weiqi Zhang and Qingjiong Zhang and Licheng Zhang and Jingjing Zhang and Huijie Zhang and Hongbo Zhang and Cuntai Zhang and Dingjun Zha and Rui Yue and Jirong Yue and Wei Yuan and Huijun Yuan and Wei Yu and Lisheng Yu and Honghua Yu and Yang Yu and Fan Yi and Chengqi Yi and Keqiang Ye and Jing Ye and Ze Yang and Tao Yang and Qi Yang and Liu Yang and Jieyu Qi and Xiaolong Fu and Renjie Chai",

note = "Publisher Copyright: {\textcopyright} Springer Nature Limited 2025.",

year = "2025",

month = nov,

doi = "10.1038/s41580-025-00883-8",

language = "English",

volume = "26",

pages = "826--847",

journal = "Nature Reviews Molecular Cell Biology",

issn = "1471-0072",

publisher = "Nature Research",

number = "11",

}

TY - JOUR

T1 - Biomarkers of ageing of humans and non-human primates

AU - Aging Biomarker Consortium

AU - Wu, Zeming

AU - Qu, Jing

AU - Zhang, Weiqi

AU - Zou, Weiguo

AU - Zhuang, Wenjuan

AU - Zhu, Zhiming

AU - Zhou, Zhongjun

AU - Zheng, Zhuozhao

AU - Zheng, Jialin C.

AU - Zhao, Yuzheng

AU - Zhao, Tongbiao

AU - Zhao, Jiajun

AU - Zhang, Zhen Lin

AU - Zhang, Xiaoqing

AU - Zhang, Weiping J.

AU - Zhang, Zhuohua

AU - Zhang, Changqing

AU - Zhang, Zhanjun

AU - Zhang, Yun Wu

AU - Zhang, Yong

AU - Zhang, Yan

AU - Zhang, Xuxiang

AU - Zhang, Xinchao

AU - Zhang, Weiqi

AU - Zhang, Qingjiong

AU - Zhang, Licheng

AU - Zhang, Jingjing

AU - Zhang, Huijie

AU - Zhang, Hongbo

AU - Zhang, Cuntai

AU - Zha, Dingjun

AU - Yue, Rui

AU - Yue, Jirong

AU - Yuan, Wei

AU - Yuan, Huijun

AU - Yu, Wei

AU - Yu, Lisheng

AU - Yu, Honghua

AU - Yu, Yang

AU - Yi, Fan

AU - Yi, Chengqi

AU - Ye, Keqiang

AU - Ye, Jing

AU - Yang, Ze

AU - Yang, Tao

AU - Yang, Qi

AU - Yang, Liu

AU - Qi, Jieyu

AU - Fu, Xiaolong

AU - Chai, Renjie

PY - 2025/11

Y1 - 2025/11

N2 - Ageing is characterized by progressive functional decline and increase in disease risk and imposes substantial burdens on human health. Identifying aging biomarkers in primates is crucial for advancing our understanding of human ageing and for informing interventions to mitigate age-related pathologies. However, a comprehensive grasp of these biomarkers is still lacking, hindering the translation of fundamental research into clinical practice. In this Review, we present the current knowledge on biomarkers of ageing at the cellular, tissue and organism levels in humans and non-human primates. Through systematic analysis of representative biomarkers across diverse biological contexts and scales, we discuss both the variability and the conservation of ageing-associated physiological changes, underscoring their importance in assessing and intervening in the ageing process. Finally, we critically assess challenges in ageing research and outline strategic avenues for future investigation.

AB - Ageing is characterized by progressive functional decline and increase in disease risk and imposes substantial burdens on human health. Identifying aging biomarkers in primates is crucial for advancing our understanding of human ageing and for informing interventions to mitigate age-related pathologies. However, a comprehensive grasp of these biomarkers is still lacking, hindering the translation of fundamental research into clinical practice. In this Review, we present the current knowledge on biomarkers of ageing at the cellular, tissue and organism levels in humans and non-human primates. Through systematic analysis of representative biomarkers across diverse biological contexts and scales, we discuss both the variability and the conservation of ageing-associated physiological changes, underscoring their importance in assessing and intervening in the ageing process. Finally, we critically assess challenges in ageing research and outline strategic avenues for future investigation.

UR - https://www.scopus.com/pages/publications/105016797992

U2 - 10.1038/s41580-025-00883-8

DO - 10.1038/s41580-025-00883-8

M3 - Review article

C2 - 40935898

AN - SCOPUS:105016797992

SN - 1471-0072

VL - 26

SP - 826

EP - 847

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

IS - 11

ER -

Biomarkers of ageing of humans and non-human primates

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