Bio-fabrication of Ca-alginate cell sheets with the electrodeposition method for hepatic lobule tissue reconstructs

  • Zeyang Liu*
  • , Masaru Takeuchi
  • , Yasuhisa Hasegawa
  • , Toshio Fukuda
  • , Qiang Huang
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Various liver tissue engineering approaches are currently under development in applications ranging from artificial liver organ transplantation to cell-based therapies. Most of them rely on the ability to encapsulate hepatocytes in three-dimensional (3D) scaffolds. Alginate cell-containing hydrogel has shown great potentials for the application of stem cell study, drug release, 3D cell culture and in vitro mimic of tissue structures or organs. We proposed a novel approach to fabricate the Ca-alginate gel sheet embedded liver cells to mimic the liver lobule tissue. Ca-alginate sheet with hepatic lobule shaped pattern was firstly deposited on a micro-electrode device based on the electrodeposition method.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages1017-1018
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: 22 Oct 201726 Oct 2017

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Country/TerritoryUnited States
CitySavannah
Period22/10/1726/10/17

Keywords

  • Alginate cell sheets
  • Electrodeposition
  • Shape-control
  • Tissue engineering

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