Base-catalyzed one-pot tandem reaction: An effective strategy for the synthesis of pyrazolo[3,4-d]pyrimidinone derivatives

Ming Xing Liu; Jia Rong Li; Kai Zheng; Huan Yao; Qi Zhang; Da Xin Shi

doi:10.1016/j.tet.2015.07.065

Base-catalyzed one-pot tandem reaction: An effective strategy for the synthesis of pyrazolo[3,4-d]pyrimidinone derivatives

Ming Xing Liu
, Jia Rong Li
, Kai Zheng
, Huan Yao
, Qi Zhang
, Da Xin Shi^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

An effective one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidinone derivatives through the tandem heterocyclization of hydrazine, methylenemalononitrile and aldehyde has been developed. This highly effective method includes nucleophilic addition, heterocyclization, substitution, intramolecular Pinner, Dimroth rearrangement and dehydroaromatization.

Original language	English
Article number	27010
Pages (from-to)	7658-7662
Number of pages	5
Journal	Tetrahedron
Volume	71
Issue number	40
DOIs	https://doi.org/10.1016/j.tet.2015.07.065
Publication status	Published - 7 Oct 2015

Keywords

Base catalysis
One-pot multicomponent heterocyclization
Pyrazolo[3,4-d]pyrimidinone

Access to Document

10.1016/j.tet.2015.07.065

Cite this

@article{ec350b10e02c487ca0904004b962da04,

title = "Base-catalyzed one-pot tandem reaction: An effective strategy for the synthesis of pyrazolo[3,4-d]pyrimidinone derivatives",

abstract = "An effective one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidinone derivatives through the tandem heterocyclization of hydrazine, methylenemalononitrile and aldehyde has been developed. This highly effective method includes nucleophilic addition, heterocyclization, substitution, intramolecular Pinner, Dimroth rearrangement and dehydroaromatization.",

keywords = "Base catalysis, One-pot multicomponent heterocyclization, Pyrazolo[3,4-d]pyrimidinone",

author = "Liu, \{Ming Xing\} and Li, \{Jia Rong\} and Kai Zheng and Huan Yao and Qi Zhang and Shi, \{Da Xin\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = oct,

day = "7",

doi = "10.1016/j.tet.2015.07.065",

language = "English",

volume = "71",

pages = "7658--7662",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd.",

number = "40",

}

TY - JOUR

T1 - Base-catalyzed one-pot tandem reaction

T2 - An effective strategy for the synthesis of pyrazolo[3,4-d]pyrimidinone derivatives

AU - Liu, Ming Xing

AU - Li, Jia Rong

AU - Zheng, Kai

AU - Yao, Huan

AU - Zhang, Qi

AU - Shi, Da Xin

PY - 2015/10/7

Y1 - 2015/10/7

N2 - An effective one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidinone derivatives through the tandem heterocyclization of hydrazine, methylenemalononitrile and aldehyde has been developed. This highly effective method includes nucleophilic addition, heterocyclization, substitution, intramolecular Pinner, Dimroth rearrangement and dehydroaromatization.

AB - An effective one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidinone derivatives through the tandem heterocyclization of hydrazine, methylenemalononitrile and aldehyde has been developed. This highly effective method includes nucleophilic addition, heterocyclization, substitution, intramolecular Pinner, Dimroth rearrangement and dehydroaromatization.

KW - Base catalysis

KW - One-pot multicomponent heterocyclization

KW - Pyrazolo[3,4-d]pyrimidinone

UR - https://www.scopus.com/pages/publications/84940461885

U2 - 10.1016/j.tet.2015.07.065

DO - 10.1016/j.tet.2015.07.065

M3 - Article

AN - SCOPUS:84940461885

SN - 0040-4020

VL - 71

SP - 7658

EP - 7662

JO - Tetrahedron

JF - Tetrahedron

IS - 40

M1 - 27010

ER -

Base-catalyzed one-pot tandem reaction: An effective strategy for the synthesis of pyrazolo[3,4-d]pyrimidinone derivatives

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this