Automated bubble-based assembly of cell-laden microgels into vascular-like microtubes

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Citations (Scopus)

Abstract

Fabrication of artificial blood vessels in micro scale significantly benefits the regeneration of functional human vascular networks. In this paper, we develop an efficient multi-microrobotic system with an innovative motorized sample holder (MSH) and two manipulators. Air is injected into the solution through a glass pipette fixed on one manipulator to create bubbles. These bubbles conduct a regular rising movement, which is utilized to assemble the 2D ring-shaped microgels fabricated in a simple micro fluidic device. With this novel bubble-based method and the robotic system, we achieve the automation of the assembly. A 1.2 mm long vascular-like microtube with an outer diameter of 200 μm is fabricated. The whole process of the bubble-based assembly is visually observed and analyzed with side view. Key parameters are characterized to improve the assembly. Results show that the automated bubble-based assembly success rate is 100% and average time cost of assembling every microgel is as low as 3.25s.

Original languageEnglish
Title of host publicationIROS Hamburg 2015 - Conference Digest
Subtitle of host publicationIEEE/RSJ International Conference on Intelligent Robots and Systems
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages798-803
Number of pages6
ISBN (Electronic)9781479999941
DOIs
Publication statusPublished - 11 Dec 2015
EventIEEE/RSJ International Conference on Intelligent Robots and Systems, IROS 2015 - Hamburg, Germany
Duration: 28 Sept 20152 Oct 2015

Publication series

NameIEEE International Conference on Intelligent Robots and Systems
Volume2015-December
ISSN (Print)2153-0858
ISSN (Electronic)2153-0866

Conference

ConferenceIEEE/RSJ International Conference on Intelligent Robots and Systems, IROS 2015
Country/TerritoryGermany
CityHamburg
Period28/09/152/10/15

Keywords

  • Assembly
  • Blood vessels
  • Fabrication
  • Lenses
  • Manipulators
  • Transforms

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