Au(I)/Au(III)-Catalyzed Sulfonylation of Aryl Iodides for the Synthesis of Various Functionalized Aryl Sulfones

Lizhu Zhang; Wenqian Du; Jiawen Wu; Rongjie Yang; E. Xiu-Tian-feng; Junfeng Wang; Zhonghua Xia

doi:10.1021/acs.orglett.4c03724

Au(I)/Au(III)-Catalyzed Sulfonylation of Aryl Iodides for the Synthesis of Various Functionalized Aryl Sulfones

Lizhu Zhang, Wenqian Du, Jiawen Wu, Rongjie Yang, E. Xiu-Tian-feng^*, Junfeng Wang^*, Zhonghua Xia^*

^*Corresponding author for this work

School of Material Science and Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A gold-catalyzed sulfonylation reaction of aryl iodides with different sodium sulfinates facilitated by the ligand-enabled Au(I)/Au(III) redox catalysis was developed. In the reaction of gold-catalyzed C−S coupling, a variety of functionalized sodium sulfinates, such as CF₃, CHF₂, CH₃, and alkyl groups, can react smoothly with aryl iodides to directly construct diversely functionalized aryl sulfones. This gold-catalyzed sulfonylation offers a complementary method for synthesizing functionalized aryl sulfones with electron-donating groups.(Figure presented.)

Original language	English
Pages (from-to)	9413-9418
Number of pages	6
Journal	Organic Letters
Volume	26
Issue number	43
DOIs	https://doi.org/10.1021/acs.orglett.4c03724
Publication status	Published - 1 Nov 2024

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title = "Au(I)/Au(III)-Catalyzed Sulfonylation of Aryl Iodides for the Synthesis of Various Functionalized Aryl Sulfones",

abstract = "A gold-catalyzed sulfonylation reaction of aryl iodides with different sodium sulfinates facilitated by the ligand-enabled Au(I)/Au(III) redox catalysis was developed. In the reaction of gold-catalyzed C−S coupling, a variety of functionalized sodium sulfinates, such as CF3, CHF2, CH3, and alkyl groups, can react smoothly with aryl iodides to directly construct diversely functionalized aryl sulfones. This gold-catalyzed sulfonylation offers a complementary method for synthesizing functionalized aryl sulfones with electron-donating groups.(Figure presented.)",

author = "Lizhu Zhang and Wenqian Du and Jiawen Wu and Rongjie Yang and E. Xiu-Tian-feng and Junfeng Wang and Zhonghua Xia",

note = "Publisher Copyright: {\textcopyright} 2024 American Chemical Society.",

year = "2024",

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doi = "10.1021/acs.orglett.4c03724",

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T1 - Au(I)/Au(III)-Catalyzed Sulfonylation of Aryl Iodides for the Synthesis of Various Functionalized Aryl Sulfones

AU - Zhang, Lizhu

AU - Du, Wenqian

AU - Wu, Jiawen

AU - Yang, Rongjie

AU - Xiu-Tian-feng, E.

AU - Wang, Junfeng

AU - Xia, Zhonghua

PY - 2024/11/1

Y1 - 2024/11/1

N2 - A gold-catalyzed sulfonylation reaction of aryl iodides with different sodium sulfinates facilitated by the ligand-enabled Au(I)/Au(III) redox catalysis was developed. In the reaction of gold-catalyzed C−S coupling, a variety of functionalized sodium sulfinates, such as CF3, CHF2, CH3, and alkyl groups, can react smoothly with aryl iodides to directly construct diversely functionalized aryl sulfones. This gold-catalyzed sulfonylation offers a complementary method for synthesizing functionalized aryl sulfones with electron-donating groups.(Figure presented.)

AB - A gold-catalyzed sulfonylation reaction of aryl iodides with different sodium sulfinates facilitated by the ligand-enabled Au(I)/Au(III) redox catalysis was developed. In the reaction of gold-catalyzed C−S coupling, a variety of functionalized sodium sulfinates, such as CF3, CHF2, CH3, and alkyl groups, can react smoothly with aryl iodides to directly construct diversely functionalized aryl sulfones. This gold-catalyzed sulfonylation offers a complementary method for synthesizing functionalized aryl sulfones with electron-donating groups.(Figure presented.)

UR - https://www.scopus.com/pages/publications/85207154820

U2 - 10.1021/acs.orglett.4c03724

DO - 10.1021/acs.orglett.4c03724

M3 - Article

AN - SCOPUS:85207154820

SN - 1523-7060

VL - 26

SP - 9413

EP - 9418

JO - Organic Letters

JF - Organic Letters

IS - 43

ER -

Au(I)/Au(III)-Catalyzed Sulfonylation of Aryl Iodides for the Synthesis of Various Functionalized Aryl Sulfones

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