Abstract
In this paper, based on Lp- Lq estimate for the Neumann heat semigroup, we investigate the asymptotic behavior for solutions to an oncolytic virotherapy model given by {ut=Δu-ξu∇·(u∇v)-ρuuz,x∈Ω,t>0,wt=Δw-ξw∇·(w∇v)-δww+ρwuz,x∈Ω,t>0,vt=-(αuu+αww)v-δvv,x∈Ω,t>0,zt=Δz-ξz∇·(z∇v)-δzz-ρzuz+βw,x∈Ω,t>0,where u, w, v and z denote the density of uninfected cancer cells, oncolytic viruses infected cancer cells, extracellular matrix and oncolytic virus particles, respectively. It is showed that when suitably regular initial data satisfy a certain small condition, infected cancer cells and virus particle populations will both become extinct asymptotically.
| Original language | English |
|---|---|
| Article number | 55 |
| Journal | Zeitschrift fur Angewandte Mathematik und Physik |
| Volume | 73 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 2022 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Asymptotic behavior
- Lp-Lq estimation
- Oncolytic viruses
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