TY - JOUR
T1 - Arrhythmogenic cardiomyopathy with left ventricle involvement/arrhythmogenic left ventricular cardiomyopathy
T2 - a clinical and MRI study
AU - Li, Guozhong
AU - Zhao, Shihua
AU - Lu, Minjie
AU - Zhang, Yan
AU - Lan, Tian
AU - Dai, Linlin
AU - Huang, Jinghan
AU - Song, Lei
AU - Yin, Gang
AU - Duan, Fujian
AU - Yin, Xiaorong
N1 - Publisher Copyright:
Copyright © 2016 by the Chinese Medical Association.
PY - 2016/2/10
Y1 - 2016/2/10
N2 - Objective: To investigate the characteristics of clinical and cardiovascular magnetic resonance imaging(CMR) of arrhythmogenic cardiomyopathy with left ventricular(ALVC) involvement. Methods: Ten cases of arrhythmogenic cardiomyopathy with left ventricular involvement and sixteen randomly chosen cases of arrhythmogenic cardiomyopathy with right ventricular (ARVC) involvement were enrolled in this study. Clinical symptoms, cardiac electrophysiological changes as well as the cardiac morpharage, ventricular functions and delayed enhancement of myocardium assessed by CMR were compared between the two groups. The size of heart chambers, global ventricular functions and the fat/ fibrosis infiltration were evaluated by turbo fast spin echo, ture FISP cine and delayed enhancement. These were statistically analyzed by independent samples t test, respectively. Results: There was no significant difference in age and gender between two groups. All the patients in two groups presented non-specific clinical manifestations with no significant differences (P>0.05) except for short of breath(P=0.034). The end-diastolic diameter of left ventricular, left ventricular end-diastolic volume index, left and right ejection fraction in ALVC and ARVC group were (64.2±7.7), (49.2±5.9) mm(t=5.551,P<0.001), (113.9±24.0), (69.2± 30.0) ml/m2 0=3.962, P<0.001), (38.5±3.1)%, (56.0±8.4)%(t=-6.733,P<0.001), (42.0±5.5) %, (18.0±7.3)% (t=8.817, P<0.001) respectively. An medium of 11 and 14 segments of fat or fat/fibrosis were found in intramural wall of the LV myocardiumin patients with ALVC, while only 0 segment(all P<0.001)was found in patients with ARVC. Conclusions: The clinical manifestations of arrhythmogenic cardiomyopathy with left ventricular involvement was similar to ARVC, however, with regarding to cardiac morphological, functional and myocardial lesions, these two diseases have different characteristics in CMR features, "one-stop-shop" MRI examination has high value in the diagnosis of arrhythmogenic cardiomyopathy with Left ventricular involvement.
AB - Objective: To investigate the characteristics of clinical and cardiovascular magnetic resonance imaging(CMR) of arrhythmogenic cardiomyopathy with left ventricular(ALVC) involvement. Methods: Ten cases of arrhythmogenic cardiomyopathy with left ventricular involvement and sixteen randomly chosen cases of arrhythmogenic cardiomyopathy with right ventricular (ARVC) involvement were enrolled in this study. Clinical symptoms, cardiac electrophysiological changes as well as the cardiac morpharage, ventricular functions and delayed enhancement of myocardium assessed by CMR were compared between the two groups. The size of heart chambers, global ventricular functions and the fat/ fibrosis infiltration were evaluated by turbo fast spin echo, ture FISP cine and delayed enhancement. These were statistically analyzed by independent samples t test, respectively. Results: There was no significant difference in age and gender between two groups. All the patients in two groups presented non-specific clinical manifestations with no significant differences (P>0.05) except for short of breath(P=0.034). The end-diastolic diameter of left ventricular, left ventricular end-diastolic volume index, left and right ejection fraction in ALVC and ARVC group were (64.2±7.7), (49.2±5.9) mm(t=5.551,P<0.001), (113.9±24.0), (69.2± 30.0) ml/m2 0=3.962, P<0.001), (38.5±3.1)%, (56.0±8.4)%(t=-6.733,P<0.001), (42.0±5.5) %, (18.0±7.3)% (t=8.817, P<0.001) respectively. An medium of 11 and 14 segments of fat or fat/fibrosis were found in intramural wall of the LV myocardiumin patients with ALVC, while only 0 segment(all P<0.001)was found in patients with ARVC. Conclusions: The clinical manifestations of arrhythmogenic cardiomyopathy with left ventricular involvement was similar to ARVC, however, with regarding to cardiac morphological, functional and myocardial lesions, these two diseases have different characteristics in CMR features, "one-stop-shop" MRI examination has high value in the diagnosis of arrhythmogenic cardiomyopathy with Left ventricular involvement.
KW - Arrhythmogenic right ventricular dysplasia
KW - Magnetic resonance imaging
KW - Ventricular dysfunction, left
UR - http://www.scopus.com/inward/record.url?scp=84962620636&partnerID=8YFLogxK
U2 - 10.3760/cma.j.issn.1005-1201.2016.02.004
DO - 10.3760/cma.j.issn.1005-1201.2016.02.004
M3 - Article
AN - SCOPUS:84962620636
SN - 1005-1201
VL - 50
SP - 95
EP - 100
JO - Zhonghua fang she xue za zhi Chinese journal of radiology
JF - Zhonghua fang she xue za zhi Chinese journal of radiology
IS - 2
ER -