Anticancer activities in vitro of stilbenes from dragon's blood on melanoma HSC-1

Fang Liu; Rong Ji Dai; Yu Lin Deng; Fang Lü

Anticancer activities in vitro of stilbenes from dragon's blood on melanoma HSC-1

Fang Liu
, Rong Ji Dai
, Yu Lin Deng
, Fang Lü^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The anticancer activities of three stilbenes on melanoma HSC-1were studied. Trans-4', 5-dihydroxy-3-methoxy-diphenylthene, trans-4', 3, 5-trihydroxy-diphenylthene (resveratrol) shows significant inhibiting proliferation effects on HSC-1 in a concentration-and time-dependent manner except trans-4'-dihydroxy-3, 5-dimethoxy-diphenylthene (pterostilbene). The apoptosis of HSC-1 was significantly increased and the cell cycles were altered by the treatments of trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol with the concentration of IC₅₀ by 72 h(p<0.001). The cell counts of G0/G1 increased obviously (p<0.001) and G0/G1, S, G2/M reduced (p<0.01). The results show that trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol inhibit cancer cell growth in vitro via inducing apoptosis and blocking cell cycles.

Original language	English
Pages (from-to)	1090-1093
Number of pages	4
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	34
Issue number	10
Publication status	Published - 1 Oct 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Activity
Anticancer
Dragon' blood
Melanoma
Stilbenes

Cite this

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title = "Anticancer activities in vitro of stilbenes from dragon's blood on melanoma HSC-1",

abstract = "The anticancer activities of three stilbenes on melanoma HSC-1were studied. Trans-4', 5-dihydroxy-3-methoxy-diphenylthene, trans-4', 3, 5-trihydroxy-diphenylthene (resveratrol) shows significant inhibiting proliferation effects on HSC-1 in a concentration-and time-dependent manner except trans-4'-dihydroxy-3, 5-dimethoxy-diphenylthene (pterostilbene). The apoptosis of HSC-1 was significantly increased and the cell cycles were altered by the treatments of trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol with the concentration of IC50 by 72 h(p<0.001). The cell counts of G0/G1 increased obviously (p<0.001) and G0/G1, S, G2/M reduced (p<0.01). The results show that trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol inhibit cancer cell growth in vitro via inducing apoptosis and blocking cell cycles.",

keywords = "Activity, Anticancer, Dragon' blood, Melanoma, Stilbenes",

author = "Fang Liu and Dai, \{Rong Ji\} and Deng, \{Yu Lin\} and Fang L{\"u}",

year = "2014",

month = oct,

day = "1",

language = "English",

volume = "34",

pages = "1090--1093",

journal = "Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology",

issn = "1001-0645",

publisher = "Beijing Institute of Technology",

number = "10",

}

TY - JOUR

T1 - Anticancer activities in vitro of stilbenes from dragon's blood on melanoma HSC-1

AU - Liu, Fang

AU - Dai, Rong Ji

AU - Deng, Yu Lin

AU - Lü, Fang

PY - 2014/10/1

Y1 - 2014/10/1

N2 - The anticancer activities of three stilbenes on melanoma HSC-1were studied. Trans-4', 5-dihydroxy-3-methoxy-diphenylthene, trans-4', 3, 5-trihydroxy-diphenylthene (resveratrol) shows significant inhibiting proliferation effects on HSC-1 in a concentration-and time-dependent manner except trans-4'-dihydroxy-3, 5-dimethoxy-diphenylthene (pterostilbene). The apoptosis of HSC-1 was significantly increased and the cell cycles were altered by the treatments of trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol with the concentration of IC50 by 72 h(p<0.001). The cell counts of G0/G1 increased obviously (p<0.001) and G0/G1, S, G2/M reduced (p<0.01). The results show that trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol inhibit cancer cell growth in vitro via inducing apoptosis and blocking cell cycles.

AB - The anticancer activities of three stilbenes on melanoma HSC-1were studied. Trans-4', 5-dihydroxy-3-methoxy-diphenylthene, trans-4', 3, 5-trihydroxy-diphenylthene (resveratrol) shows significant inhibiting proliferation effects on HSC-1 in a concentration-and time-dependent manner except trans-4'-dihydroxy-3, 5-dimethoxy-diphenylthene (pterostilbene). The apoptosis of HSC-1 was significantly increased and the cell cycles were altered by the treatments of trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol with the concentration of IC50 by 72 h(p<0.001). The cell counts of G0/G1 increased obviously (p<0.001) and G0/G1, S, G2/M reduced (p<0.01). The results show that trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol inhibit cancer cell growth in vitro via inducing apoptosis and blocking cell cycles.

KW - Activity

KW - Anticancer

KW - Dragon' blood

KW - Melanoma

KW - Stilbenes

UR - https://www.scopus.com/pages/publications/84920087490

M3 - Article

AN - SCOPUS:84920087490

SN - 1001-0645

VL - 34

SP - 1090

EP - 1093

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 10

ER -

Anticancer activities in vitro of stilbenes from dragon's blood on melanoma HSC-1

Abstract

UN SDGs

Keywords

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