TY - JOUR
T1 - Analysis of drugs illegally added into Chinese traditional patent medicine using surface-enhanced Raman scattering
AU - Zhang, Yan
AU - Huang, Xiaoyan
AU - Liu, Wenfang
AU - Cheng, Zeneng
AU - Chen, Chuanpin
AU - Yin, Lihui
PY - 2013
Y1 - 2013
N2 - Illegal chemicals, which could cause unpredictable side effects, may be added into traditional Chinese medicine (TCM) for a rapid healing effect. In this report, a surface-enhanced Raman scattering (SERS) analysis method for five kinds of illegally added drugs (rosiglitazone maleate, phenformin hydrochloride, metformin hydrochloride, pioglitazone hydrochloride and sibutramine hydrochloride) in Chinese traditional patent medicine (CTPM) has been demonstrated, including simultaneous detections of drug mixtures with CTPM. Silver colloidal, prepared by a sodium citrate reaction, was used as a SERS substrate. The optimum pH condition for each drug has also been explored because of its combined effect on protonation, surface charge, repulsion of an analyte and nanoparticles. Furthermore, the simultaneous detection of two or three kinds of these chemicals has been carried out. Characteristic peaks are employed for qualitative analysis. This is the first research using SERS for the analysis of drug mixtures in CTPM without any separation process.
AB - Illegal chemicals, which could cause unpredictable side effects, may be added into traditional Chinese medicine (TCM) for a rapid healing effect. In this report, a surface-enhanced Raman scattering (SERS) analysis method for five kinds of illegally added drugs (rosiglitazone maleate, phenformin hydrochloride, metformin hydrochloride, pioglitazone hydrochloride and sibutramine hydrochloride) in Chinese traditional patent medicine (CTPM) has been demonstrated, including simultaneous detections of drug mixtures with CTPM. Silver colloidal, prepared by a sodium citrate reaction, was used as a SERS substrate. The optimum pH condition for each drug has also been explored because of its combined effect on protonation, surface charge, repulsion of an analyte and nanoparticles. Furthermore, the simultaneous detection of two or three kinds of these chemicals has been carried out. Characteristic peaks are employed for qualitative analysis. This is the first research using SERS for the analysis of drug mixtures in CTPM without any separation process.
KW - Chinese traditional patent medicines
KW - Illegal additives
KW - Surface-enhanced Raman spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=84885917761&partnerID=8YFLogxK
U2 - 10.2116/analsci.29.985
DO - 10.2116/analsci.29.985
M3 - Article
C2 - 24107564
AN - SCOPUS:84885917761
SN - 0910-6340
VL - 29
SP - 985
EP - 990
JO - Analytical Sciences
JF - Analytical Sciences
IS - 10
ER -