Analysis of catechol quinoline substance in corpus striatum and hippocampus from brains of diabetic rat models by HPLC-MS

Diabetes is a risk factor for Parkinson's disease (PD). There are statistics data indicating that the prevalence of PD among patients with diabetes was higher compared with the normal people. To date, little is known about the molecular events underlying hyperglycemia-induced PD. In this paper, the catechol quinoline substance in corpus striatum (ST) and hippocampus from the brains of diabetic rats model and control rats was analyzed by HPLCMS. 1l-acetyl-6, 7-dihyroxy-1, 2, 3, 4- tetrahydro-isoquinoline (ADTIQ) and Salsolinol were found significantly elevated compared with control. Microcontent N-methylsalsolinol was found in the brains of diabetic rat model. These results suggested that hyperglycemia will induce the aldehydes to increase and enhance the catechol quinoline substance to accumulate. Thus mitochondrial dysfunction occurred and the neuron died; at last leading diabetes patients to Parkinson's disease.