An improved synthesis of trantinterol

H. Wen; L. Qin; L. Pan; J. Li; M. Cheng

doi:10.1007/s11094-012-0788-y

An improved synthesis of trantinterol

H. Wen^*
, L. Qin
, L. Pan
, J. Li
, M. Cheng

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

An efficient synthesis of 2-(4-amino-3-chloro-5-trifluoromethylphenyl)-2-t- butylamino-ethanol (trantinterol), a selective β₂ -adrenoceptor agonist, has been achieved from inexpensive and commercially available starting material. The synthesis involves the conversion of aryl iodide to aldehyde catalyzed by PdCl₂ (dppf) as a key step.

Original language	English
Pages (from-to)	313-315
Number of pages	3
Journal	Pharmaceutical Chemistry Journal
Volume	46
Issue number	5
DOIs	https://doi.org/10.1007/s11094-012-0788-y
Publication status	Published - Aug 2012

Keywords

Palladium catalyzed carbonylation
Synthesis
Trantinterol

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10.1007/s11094-012-0788-y

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title = "An improved synthesis of trantinterol",

abstract = "An efficient synthesis of 2-(4-amino-3-chloro-5-trifluoromethylphenyl)-2-t- butylamino-ethanol (trantinterol), a selective β2 -adrenoceptor agonist, has been achieved from inexpensive and commercially available starting material. The synthesis involves the conversion of aryl iodide to aldehyde catalyzed by PdCl2 (dppf) as a key step.",

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AU - Wen, H.

AU - Qin, L.

AU - Pan, L.

AU - Li, J.

AU - Cheng, M.

PY - 2012/8

Y1 - 2012/8

N2 - An efficient synthesis of 2-(4-amino-3-chloro-5-trifluoromethylphenyl)-2-t- butylamino-ethanol (trantinterol), a selective β2 -adrenoceptor agonist, has been achieved from inexpensive and commercially available starting material. The synthesis involves the conversion of aryl iodide to aldehyde catalyzed by PdCl2 (dppf) as a key step.

AB - An efficient synthesis of 2-(4-amino-3-chloro-5-trifluoromethylphenyl)-2-t- butylamino-ethanol (trantinterol), a selective β2 -adrenoceptor agonist, has been achieved from inexpensive and commercially available starting material. The synthesis involves the conversion of aryl iodide to aldehyde catalyzed by PdCl2 (dppf) as a key step.

KW - Palladium catalyzed carbonylation

KW - Synthesis

KW - Trantinterol

UR - https://www.scopus.com/pages/publications/85028103052

U2 - 10.1007/s11094-012-0788-y

DO - 10.1007/s11094-012-0788-y

M3 - Article

AN - SCOPUS:85028103052

SN - 0091-150X

VL - 46

SP - 313

EP - 315

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

IS - 5

ER -

An improved synthesis of trantinterol

Abstract

Keywords

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