An automated method with anchor-free detection and U-shaped segmentation for nuclei instance segmentation

Nuclei segmentation plays an important role in cancer diagnosis. Automated methods for digital pathology become popular due to the developments of deep learning and neural networks. However, this task still faces challenges. Most of current techniques cannot be applied directly because of the clustered state and the large number of nuclei in images. Moreover, anchor-based methods for object detection lead a huge amount of calculation, which is even worse on pathological images with a large target density. To address these issues, we propose a novel network with an anchor-free detection and a U-shaped segmentation. An altered feature enhancement module is attached to improve the performance in dense target detection. Meanwhile, the U-Shaped structure in segmentation block ensures the aggregation of features in different dimensions generated from the backbone network. We evaluate our work on a Multi-Organ Nuclei Segmentation dataset from MICCAI 2018 challenge. In comparisons with others, our proposed method achieves state-of-the-art performance.