Alterations in emotional and salience responses to positive stimuli in major depressive disorder

Yang Yang; Lei Feng; Kazuyuki Imamura; Xiaojing Yang; Huaizhou Li; Gang Wang; Bin Hu; Shengfu Lu; Ning Zhong

doi:10.1007/978-3-319-47103-7_12

Alterations in emotional and salience responses to positive stimuli in major depressive disorder

Yang Yang, Lei Feng, Kazuyuki Imamura, Xiaojing Yang, Huaizhou Li, Gang Wang, Bin Hu, Shengfu Lu, Ning Zhong^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

To find out the influences on the emotionality and attentional deployment caused by depression, we recruited 19 MDD patients and 19 healthy controls, and implemented a task-state fMRI experiment using a distraction task paradigm. Our results showed relatively decreased brain activation in the right precuneus and left DLPFC, in the MDD group compared with the healthy group across the positive, neutral, and negative task conditions. During only the positive condition, decreased subcortical responses and concurrently reduced brain activation in the salience network were found only in MDD patients. Further brain-symptom analysis demonstrated significant correlation between alterations in the key region of the salience network and the depressive severity of the patients. Our findings suggest a crucial role of aberrant salience processes (especially in the anterior insulae) in the abnormal perception of positive stimuli in MDD patients, which is likely to be the underlying pathology of the anhedonia.

Original language	English
Title of host publication	Brain Informatics and Health - International Conference, BIH 2016, Proceedings
Editors	Hesham Ali, Yong Shi, Giorgio A. Ascoli, Deepak Khazanchi, Michael Hawrylycz
Publisher	Springer Verlag
Pages	114-123
Number of pages	10
ISBN (Print)	9783319471020
DOIs	https://doi.org/10.1007/978-3-319-47103-7_12
Publication status	Published - 2016
Externally published	Yes
Event	International Conference on Brain Informatics and Health, BIH 2016 - Omaha, United States Duration: 13 Oct 2016 → 16 Oct 2016

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	9919 LNAI
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	International Conference on Brain Informatics and Health, BIH 2016
Country/Territory	United States
City	Omaha
Period	13/10/16 → 16/10/16

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10.1007/978-3-319-47103-7_12

Cite this

Yang, Y., Feng, L., Imamura, K., Yang, X., Li, H., Wang, G., Hu, B., Lu, S., & Zhong, N. (2016). Alterations in emotional and salience responses to positive stimuli in major depressive disorder. In H. Ali, Y. Shi, G. A. Ascoli, D. Khazanchi, & M. Hawrylycz (Eds.), Brain Informatics and Health - International Conference, BIH 2016, Proceedings (pp. 114-123). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 9919 LNAI). Springer Verlag. https://doi.org/10.1007/978-3-319-47103-7_12

Yang, Yang ; Feng, Lei ; Imamura, Kazuyuki et al. / Alterations in emotional and salience responses to positive stimuli in major depressive disorder. Brain Informatics and Health - International Conference, BIH 2016, Proceedings. editor / Hesham Ali ; Yong Shi ; Giorgio A. Ascoli ; Deepak Khazanchi ; Michael Hawrylycz. Springer Verlag, 2016. pp. 114-123 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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title = "Alterations in emotional and salience responses to positive stimuli in major depressive disorder",

abstract = "To find out the influences on the emotionality and attentional deployment caused by depression, we recruited 19 MDD patients and 19 healthy controls, and implemented a task-state fMRI experiment using a distraction task paradigm. Our results showed relatively decreased brain activation in the right precuneus and left DLPFC, in the MDD group compared with the healthy group across the positive, neutral, and negative task conditions. During only the positive condition, decreased subcortical responses and concurrently reduced brain activation in the salience network were found only in MDD patients. Further brain-symptom analysis demonstrated significant correlation between alterations in the key region of the salience network and the depressive severity of the patients. Our findings suggest a crucial role of aberrant salience processes (especially in the anterior insulae) in the abnormal perception of positive stimuli in MDD patients, which is likely to be the underlying pathology of the anhedonia.",

author = "Yang Yang and Lei Feng and Kazuyuki Imamura and Xiaojing Yang and Huaizhou Li and Gang Wang and Bin Hu and Shengfu Lu and Ning Zhong",

note = "Publisher Copyright: {\textcopyright} Springer International Publishing AG 2016.; International Conference on Brain Informatics and Health, BIH 2016 ; Conference date: 13-10-2016 Through 16-10-2016",

year = "2016",

doi = "10.1007/978-3-319-47103-7_12",

language = "English",

isbn = "9783319471020",

series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",

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editor = "Hesham Ali and Yong Shi and Ascoli, {Giorgio A.} and Deepak Khazanchi and Michael Hawrylycz",

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Yang, Y, Feng, L, Imamura, K, Yang, X, Li, H, Wang, G, Hu, B, Lu, S & Zhong, N 2016, Alterations in emotional and salience responses to positive stimuli in major depressive disorder. in H Ali, Y Shi, GA Ascoli, D Khazanchi & M Hawrylycz (eds), Brain Informatics and Health - International Conference, BIH 2016, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 9919 LNAI, Springer Verlag, pp. 114-123, International Conference on Brain Informatics and Health, BIH 2016, Omaha, United States, 13/10/16. https://doi.org/10.1007/978-3-319-47103-7_12

Alterations in emotional and salience responses to positive stimuli in major depressive disorder. / Yang, Yang; Feng, Lei; Imamura, Kazuyuki et al.
Brain Informatics and Health - International Conference, BIH 2016, Proceedings. ed. / Hesham Ali; Yong Shi; Giorgio A. Ascoli; Deepak Khazanchi; Michael Hawrylycz. Springer Verlag, 2016. p. 114-123 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 9919 LNAI).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Alterations in emotional and salience responses to positive stimuli in major depressive disorder

AU - Yang, Yang

AU - Feng, Lei

AU - Imamura, Kazuyuki

AU - Yang, Xiaojing

AU - Li, Huaizhou

AU - Wang, Gang

AU - Hu, Bin

AU - Lu, Shengfu

AU - Zhong, Ning

N1 - Publisher Copyright: © Springer International Publishing AG 2016.

PY - 2016

Y1 - 2016

N2 - To find out the influences on the emotionality and attentional deployment caused by depression, we recruited 19 MDD patients and 19 healthy controls, and implemented a task-state fMRI experiment using a distraction task paradigm. Our results showed relatively decreased brain activation in the right precuneus and left DLPFC, in the MDD group compared with the healthy group across the positive, neutral, and negative task conditions. During only the positive condition, decreased subcortical responses and concurrently reduced brain activation in the salience network were found only in MDD patients. Further brain-symptom analysis demonstrated significant correlation between alterations in the key region of the salience network and the depressive severity of the patients. Our findings suggest a crucial role of aberrant salience processes (especially in the anterior insulae) in the abnormal perception of positive stimuli in MDD patients, which is likely to be the underlying pathology of the anhedonia.

AB - To find out the influences on the emotionality and attentional deployment caused by depression, we recruited 19 MDD patients and 19 healthy controls, and implemented a task-state fMRI experiment using a distraction task paradigm. Our results showed relatively decreased brain activation in the right precuneus and left DLPFC, in the MDD group compared with the healthy group across the positive, neutral, and negative task conditions. During only the positive condition, decreased subcortical responses and concurrently reduced brain activation in the salience network were found only in MDD patients. Further brain-symptom analysis demonstrated significant correlation between alterations in the key region of the salience network and the depressive severity of the patients. Our findings suggest a crucial role of aberrant salience processes (especially in the anterior insulae) in the abnormal perception of positive stimuli in MDD patients, which is likely to be the underlying pathology of the anhedonia.

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DO - 10.1007/978-3-319-47103-7_12

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AN - SCOPUS:84989926181

SN - 9783319471020

T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

SP - 114

EP - 123

BT - Brain Informatics and Health - International Conference, BIH 2016, Proceedings

A2 - Ali, Hesham

A2 - Shi, Yong

A2 - Ascoli, Giorgio A.

A2 - Khazanchi, Deepak

A2 - Hawrylycz, Michael

PB - Springer Verlag

T2 - International Conference on Brain Informatics and Health, BIH 2016

Y2 - 13 October 2016 through 16 October 2016

ER -

Yang Y, Feng L, Imamura K, Yang X, Li H, Wang G et al. Alterations in emotional and salience responses to positive stimuli in major depressive disorder. In Ali H, Shi Y, Ascoli GA, Khazanchi D, Hawrylycz M, editors, Brain Informatics and Health - International Conference, BIH 2016, Proceedings. Springer Verlag. 2016. p. 114-123. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-319-47103-7_12

Alterations in emotional and salience responses to positive stimuli in major depressive disorder

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