Advances in the Treatment of Sensorineural Hearing Loss: From Traditional Therapies to Stem Cell and Gene Therapies

Ruirui Chen; Yang Zhang; Zhe Li; Renjie Chai

doi:10.1002/adsr.202500180

Advances in the Treatment of Sensorineural Hearing Loss: From Traditional Therapies to Stem Cell and Gene Therapies

Ruirui Chen
, Yang Zhang^*
, Zhe Li^*
, Renjie Chai^*

^*Corresponding author for this work

Beijing Institute of Technology
Shenzhen Institute of Advanced Technology
Southeast University, Nanjing
Nantong University
University of Electronic Science and Technology of China
Southeast University Shenzhen Research Institute

Research output: Contribution to journal › Review article › peer-review

Abstract

Sensorineural hearing loss (SNHL) occurs in 1.5 billion globally, primary driven by damage of cochlear hair cells and spiral ganglion neurons. This review systematically describes several treatment strategies for SNHL. Traditional treatments such as drug therapies consisting of direct drug delivery and carrier-mediated drug delivery, and physical therapies including hearing aids and hearing implants, have limitations. Emerging stem cell therapy shows promise in regenerating damaged inner ear hair cells, while gene therapy targets key deafness genes, offering potential cures for hereditary hearing loss. Future research should focus on optimizing these strategies to overcome current challenges and improve outcomes for patients with SNHL.

Original language	English
Article number	e00180
Journal	Advanced Sensor Research
Volume	5
Issue number	4
DOIs	https://doi.org/10.1002/adsr.202500180
Publication status	Published - Apr 2026
Externally published	Yes

Keywords

drug treatment
gene therapy
organoids
sensorineural hearing loss
stem cell

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10.1002/adsr.202500180

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title = "Advances in the Treatment of Sensorineural Hearing Loss: From Traditional Therapies to Stem Cell and Gene Therapies",

abstract = "Sensorineural hearing loss (SNHL) occurs in 1.5 billion globally, primary driven by damage of cochlear hair cells and spiral ganglion neurons. This review systematically describes several treatment strategies for SNHL. Traditional treatments such as drug therapies consisting of direct drug delivery and carrier-mediated drug delivery, and physical therapies including hearing aids and hearing implants, have limitations. Emerging stem cell therapy shows promise in regenerating damaged inner ear hair cells, while gene therapy targets key deafness genes, offering potential cures for hereditary hearing loss. Future research should focus on optimizing these strategies to overcome current challenges and improve outcomes for patients with SNHL.",

keywords = "drug treatment, gene therapy, organoids, sensorineural hearing loss, stem cell",

author = "Ruirui Chen and Yang Zhang and Zhe Li and Renjie Chai",

note = "Publisher Copyright: {\textcopyright} 2026 The Author(s). Advanced Sensor Research published by Wiley-VCH GmbH.",

year = "2026",

month = apr,

doi = "10.1002/adsr.202500180",

language = "English",

volume = "5",

journal = "Advanced Sensor Research",

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TY - JOUR

T1 - Advances in the Treatment of Sensorineural Hearing Loss

T2 - From Traditional Therapies to Stem Cell and Gene Therapies

AU - Chen, Ruirui

AU - Zhang, Yang

AU - Li, Zhe

AU - Chai, Renjie

PY - 2026/4

Y1 - 2026/4

N2 - Sensorineural hearing loss (SNHL) occurs in 1.5 billion globally, primary driven by damage of cochlear hair cells and spiral ganglion neurons. This review systematically describes several treatment strategies for SNHL. Traditional treatments such as drug therapies consisting of direct drug delivery and carrier-mediated drug delivery, and physical therapies including hearing aids and hearing implants, have limitations. Emerging stem cell therapy shows promise in regenerating damaged inner ear hair cells, while gene therapy targets key deafness genes, offering potential cures for hereditary hearing loss. Future research should focus on optimizing these strategies to overcome current challenges and improve outcomes for patients with SNHL.

AB - Sensorineural hearing loss (SNHL) occurs in 1.5 billion globally, primary driven by damage of cochlear hair cells and spiral ganglion neurons. This review systematically describes several treatment strategies for SNHL. Traditional treatments such as drug therapies consisting of direct drug delivery and carrier-mediated drug delivery, and physical therapies including hearing aids and hearing implants, have limitations. Emerging stem cell therapy shows promise in regenerating damaged inner ear hair cells, while gene therapy targets key deafness genes, offering potential cures for hereditary hearing loss. Future research should focus on optimizing these strategies to overcome current challenges and improve outcomes for patients with SNHL.

KW - drug treatment

KW - gene therapy

KW - organoids

KW - sensorineural hearing loss

KW - stem cell

UR - https://www.scopus.com/pages/publications/105036433361

U2 - 10.1002/adsr.202500180

DO - 10.1002/adsr.202500180

M3 - Review article

AN - SCOPUS:105036433361

SN - 2751-1219

VL - 5

JO - Advanced Sensor Research

JF - Advanced Sensor Research

IS - 4

M1 - e00180

ER -

Advances in the Treatment of Sensorineural Hearing Loss: From Traditional Therapies to Stem Cell and Gene Therapies

Abstract

Keywords

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