Abstract
This study presents an integrated digital microfluidic (DMF) platform combined with a surface-enhanced Raman spectroscopy (SERS) sensor for automated on-chip sample processing and detection. The system utilizes embossing technology to fabricate a semi-transparent SERS amplification stack (STSAS) integrated directly onto the DMF chip, enabling efficient exosome isolation and label-free SERS detection. Experimental results show a further 33% enhancement in SERS signal intensity, demonstrating the system's high sensitivity, stability, and reproducibility. The platform offers a versatile solution for real-time diagnostics, biomarker detection, and disease monitoring, with applications in clinical and environmental analysis.
| Original language | English |
|---|---|
| Pages (from-to) | 882-885 |
| Number of pages | 4 |
| Journal | International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers |
| Issue number | 2025 |
| DOIs | |
| Publication status | Published - 2025 |
| Event | 23rd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2025 - Orlando, United States Duration: 29 Jun 2025 → 3 Jul 2025 |
Keywords
- Biosensing
- Digital Microfluidics (DMF)
- On-Chip Detection
- Surface-Enhanced Raman Spectroscopy (SERS)
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