Activation of Pyrazines by a Mg–Mg-bonded Compound: Reduction, Homocoupling, and Formation of Metallomacrocycles

Zhenzhou Sun; Yongsheng Li; Li Yang; Jianqi Geng; Yanxia Zhao; Ji Hu Su; Biao Wu; Xiao Juan Yang

doi:10.1021/acs.inorgchem.6c00792

Activation of Pyrazines by a Mg–Mg-bonded Compound: Reduction, Homocoupling, and Formation of Metallomacrocycles

Zhenzhou Sun
, Yongsheng Li
, Li Yang
, Jianqi Geng
, Yanxia Zhao
, Ji Hu Su
, Biao Wu
, Xiao Juan Yang^*

^*Corresponding author for this work

Beijing Institute of Technology
Northwest University China
University of Science and Technology of China

Research output: Contribution to journal › Article › peer-review

Abstract

The α-diimine-ligated Mg–Mg-bonded compound [K(THF)₃]₂[LMg–MgL] (1, L = [(2,6-iPr₂C₆H₃)NC(CH₃)]₂^2–) can effectively promote the reduction of pyrazine (Pyz) and derivatives under ambient conditions. Reaction of 1 with 1 equiv of pyrazines (Pyz, 2-MePyz, and 2,5-Me₂Pyz) caused two-electron reduction of pyrazines to the dianion (R_nPyz^2–), which bridges two [LMg(II)] fragments to yield dinuclear complexes [K(THF)₂]₂[L^2–(THF)Mg^II(μ-R_nPyz^2–)Mg^II(THF)L^2–] (2–4). When 2 equiv of pyrazine substrates were used, the tetranuclear square complexes, featuring pyrazine radical anions (2,3-Me₂Pyz)^•– (5) or reductive C–C coupling of Pyz (6), were isolated. Moreover, in the dinuclear complex [L^•–Mg^II(μ-Phz^2–)Mg^IIL^•–] (8), the original dianion of α-diimine, L^2–, was oxidized to a monoanion (L^•–), and phenazine (Phz) was reduced to a dianion.

Original language	English
Pages (from-to)	11817-11826
Number of pages	10
Journal	Inorganic Chemistry
Volume	65
Issue number	21
DOIs	https://doi.org/10.1021/acs.inorgchem.6c00792
Publication status	Published - 1 Jun 2026
Externally published	Yes

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10.1021/acs.inorgchem.6c00792

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@article{3a3d41234e764de092689dc13438adf8,

title = "Activation of Pyrazines by a Mg{\textendash}Mg-bonded Compound: Reduction, Homocoupling, and Formation of Metallomacrocycles",

abstract = "The α-diimine-ligated Mg{\textendash}Mg-bonded compound [K(THF)3]2[LMg{\textendash}MgL] (1, L = [(2,6-iPr2C6H3)NC(CH3)]22{\textendash}) can effectively promote the reduction of pyrazine (Pyz) and derivatives under ambient conditions. Reaction of 1 with 1 equiv of pyrazines (Pyz, 2-MePyz, and 2,5-Me2Pyz) caused two-electron reduction of pyrazines to the dianion (RnPyz2{\textendash}), which bridges two [LMg(II)] fragments to yield dinuclear complexes [K(THF)2]2[L2{\textendash}(THF)MgII(μ-RnPyz2{\textendash})MgII(THF)L2{\textendash}] (2{\textendash}4). When 2 equiv of pyrazine substrates were used, the tetranuclear square complexes, featuring pyrazine radical anions (2,3-Me2Pyz)•{\textendash} (5) or reductive C{\textendash}C coupling of Pyz (6), were isolated. Moreover, in the dinuclear complex [L•{\textendash}MgII(μ-Phz2{\textendash})MgIIL•{\textendash}] (8), the original dianion of α-diimine, L2{\textendash}, was oxidized to a monoanion (L•{\textendash}), and phenazine (Phz) was reduced to a dianion.",

author = "Zhenzhou Sun and Yongsheng Li and Li Yang and Jianqi Geng and Yanxia Zhao and Su, \{Ji Hu\} and Biao Wu and Yang, \{Xiao Juan\}",

note = "Publisher Copyright: {\textcopyright} 2026 American Chemical Society",

year = "2026",

month = jun,

day = "1",

doi = "10.1021/acs.inorgchem.6c00792",

language = "English",

volume = "65",

pages = "11817--11826",

journal = "Inorganic Chemistry",

issn = "0020-1669",

publisher = "American Chemical Society",

number = "21",

}

TY - JOUR

T1 - Activation of Pyrazines by a Mg–Mg-bonded Compound

T2 - Reduction, Homocoupling, and Formation of Metallomacrocycles

AU - Sun, Zhenzhou

AU - Li, Yongsheng

AU - Yang, Li

AU - Geng, Jianqi

AU - Zhao, Yanxia

AU - Su, Ji Hu

AU - Wu, Biao

AU - Yang, Xiao Juan

PY - 2026/6/1

Y1 - 2026/6/1

N2 - The α-diimine-ligated Mg–Mg-bonded compound [K(THF)3]2[LMg–MgL] (1, L = [(2,6-iPr2C6H3)NC(CH3)]22–) can effectively promote the reduction of pyrazine (Pyz) and derivatives under ambient conditions. Reaction of 1 with 1 equiv of pyrazines (Pyz, 2-MePyz, and 2,5-Me2Pyz) caused two-electron reduction of pyrazines to the dianion (RnPyz2–), which bridges two [LMg(II)] fragments to yield dinuclear complexes [K(THF)2]2[L2–(THF)MgII(μ-RnPyz2–)MgII(THF)L2–] (2–4). When 2 equiv of pyrazine substrates were used, the tetranuclear square complexes, featuring pyrazine radical anions (2,3-Me2Pyz)•– (5) or reductive C–C coupling of Pyz (6), were isolated. Moreover, in the dinuclear complex [L•–MgII(μ-Phz2–)MgIIL•–] (8), the original dianion of α-diimine, L2–, was oxidized to a monoanion (L•–), and phenazine (Phz) was reduced to a dianion.

AB - The α-diimine-ligated Mg–Mg-bonded compound [K(THF)3]2[LMg–MgL] (1, L = [(2,6-iPr2C6H3)NC(CH3)]22–) can effectively promote the reduction of pyrazine (Pyz) and derivatives under ambient conditions. Reaction of 1 with 1 equiv of pyrazines (Pyz, 2-MePyz, and 2,5-Me2Pyz) caused two-electron reduction of pyrazines to the dianion (RnPyz2–), which bridges two [LMg(II)] fragments to yield dinuclear complexes [K(THF)2]2[L2–(THF)MgII(μ-RnPyz2–)MgII(THF)L2–] (2–4). When 2 equiv of pyrazine substrates were used, the tetranuclear square complexes, featuring pyrazine radical anions (2,3-Me2Pyz)•– (5) or reductive C–C coupling of Pyz (6), were isolated. Moreover, in the dinuclear complex [L•–MgII(μ-Phz2–)MgIIL•–] (8), the original dianion of α-diimine, L2–, was oxidized to a monoanion (L•–), and phenazine (Phz) was reduced to a dianion.

UR - https://www.scopus.com/pages/publications/105040858471

U2 - 10.1021/acs.inorgchem.6c00792

DO - 10.1021/acs.inorgchem.6c00792

M3 - Article

C2 - 42152222

AN - SCOPUS:105040858471

SN - 0020-1669

VL - 65

SP - 11817

EP - 11826

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 21

ER -

Activation of Pyrazines by a Mg–Mg-bonded Compound: Reduction, Homocoupling, and Formation of Metallomacrocycles

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