TY - JOUR
T1 - Acetylsalicylic acid electrochemical sensor based on PATP-AuNPs modified molecularly imprinted polymer film
AU - Wang, Zhihua
AU - Li, Hui
AU - Chen, Jing
AU - Xue, Zhonghua
AU - Wu, Bowan
AU - Lu, Xiaoquan
PY - 2011/9/15
Y1 - 2011/9/15
N2 - A novel electrochemical sensor based on molecularly imprinted polymer film has been developed for aspirin detection. The sensitive film was prepared by co-polymerization of p-aminothiophenol (p-ATP) and HAuCl4 on the Au electrode surface. First, p-ATP was self-assembled on the Au electrode surface by the formation of Au-S bonds. Then, the acetylsalicylic acid (ASA) template was assembled onto the monolayer of p-ATP through the hydrogen-bonding interaction between amino group (p-ATP) and oxygen (ASA). Finally, a conductive hybrid membrane was fabricated at the surface of Au electrode by the co-polymerization in the mixing solution containing additional p-ATP, HAuCl 4 and ASA template. Meanwhile, the ASA was spontaneously imprinted into the poly-aminothiophenol gold nanoparticles (PATP-AuNPs) complex film. The amount of imprinted sites at the PATP-AuNPs film significantly increases due to the additional replenishment of ASA templates. With the significant increasing of imprinted sites and doped gold nanoparticles, the sensitivity of the molecular imprinted polymer (MIP) electrode gradually increased. The molecularly imprinted sensor was characterized by electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV), and cyclic voltammetry (CV). The linear relationships between current and logarithmic concentration were obtained in the range from 1 nmol L-1 to 0.1 μmol L-1 and 0.7 μmol L-1 to 0.1 mmol L-1. The detection limit of 0.3 nmol L-1 was achieved. This molecularly imprinted sensor for the determination of ASA has high sensitivity, good selectivity and reproducibility, with the testing in some biological fluids also has good selectivity and recovery.
AB - A novel electrochemical sensor based on molecularly imprinted polymer film has been developed for aspirin detection. The sensitive film was prepared by co-polymerization of p-aminothiophenol (p-ATP) and HAuCl4 on the Au electrode surface. First, p-ATP was self-assembled on the Au electrode surface by the formation of Au-S bonds. Then, the acetylsalicylic acid (ASA) template was assembled onto the monolayer of p-ATP through the hydrogen-bonding interaction between amino group (p-ATP) and oxygen (ASA). Finally, a conductive hybrid membrane was fabricated at the surface of Au electrode by the co-polymerization in the mixing solution containing additional p-ATP, HAuCl 4 and ASA template. Meanwhile, the ASA was spontaneously imprinted into the poly-aminothiophenol gold nanoparticles (PATP-AuNPs) complex film. The amount of imprinted sites at the PATP-AuNPs film significantly increases due to the additional replenishment of ASA templates. With the significant increasing of imprinted sites and doped gold nanoparticles, the sensitivity of the molecular imprinted polymer (MIP) electrode gradually increased. The molecularly imprinted sensor was characterized by electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV), and cyclic voltammetry (CV). The linear relationships between current and logarithmic concentration were obtained in the range from 1 nmol L-1 to 0.1 μmol L-1 and 0.7 μmol L-1 to 0.1 mmol L-1. The detection limit of 0.3 nmol L-1 was achieved. This molecularly imprinted sensor for the determination of ASA has high sensitivity, good selectivity and reproducibility, with the testing in some biological fluids also has good selectivity and recovery.
KW - Acetylsalicylic acid
KW - Co-polymerization
KW - Gold nanoparticles
KW - Molecularly imprinting
KW - Poly-aminothiophenol
UR - http://www.scopus.com/inward/record.url?scp=79961128811&partnerID=8YFLogxK
U2 - 10.1016/j.talanta.2011.06.067
DO - 10.1016/j.talanta.2011.06.067
M3 - Article
AN - SCOPUS:79961128811
SN - 0039-9140
VL - 85
SP - 1672
EP - 1679
JO - Talanta
JF - Talanta
IS - 3
ER -