A single-atom Fe-N4 catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection

Wenjie Ma; Junjie Mao; Xiaoti Yang; Cong Pan; Wenxing Chen; Ming Wang; Ping Yu; Lanqun Mao; Yadong Li

doi:10.1039/c8cc08116f

A single-atom Fe-N₄ catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection

Wenjie Ma
, Junjie Mao
, Xiaoti Yang
, Cong Pan
, Wenxing Chen
, Ming Wang
, Ping Yu
, Lanqun Mao^*
, Yadong Li

^*Corresponding author for this work

School of Material Science and Engineering

Chinese Academy of Sciences
University of Chinese Academy of Sciences
Anhui Normal University
Tsinghua University

Research output: Contribution to journal › Article › peer-review

237 Citations (Scopus)

Abstract

Atomically dispersed Fe-N₄ sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.

Original language	English
Pages (from-to)	159-162
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	2
DOIs	https://doi.org/10.1039/c8cc08116f
Publication status	Published - 2019

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10.1039/c8cc08116f

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title = "A single-atom Fe-N4 catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection",

abstract = "Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.",

author = "Wenjie Ma and Junjie Mao and Xiaoti Yang and Cong Pan and Wenxing Chen and Ming Wang and Ping Yu and Lanqun Mao and Yadong Li",

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T1 - A single-atom Fe-N4 catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection

AU - Ma, Wenjie

AU - Mao, Junjie

AU - Yang, Xiaoti

AU - Pan, Cong

AU - Chen, Wenxing

AU - Wang, Ming

AU - Yu, Ping

AU - Mao, Lanqun

AU - Li, Yadong

PY - 2019

Y1 - 2019

N2 - Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.

AB - Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.

UR - https://www.scopus.com/pages/publications/85058884694

U2 - 10.1039/c8cc08116f

DO - 10.1039/c8cc08116f

M3 - Article

C2 - 30465670

AN - SCOPUS:85058884694

SN - 1359-7345

VL - 55

SP - 159

EP - 162

JO - Chemical Communications

JF - Chemical Communications

IS - 2

ER -

A single-atom Fe-N₄ catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection

Abstract

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