A single-atom Fe-N4 catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection

Wenjie Ma; Junjie Mao; Xiaoti Yang; Cong Pan; Wenxing Chen; Ming Wang; Ping Yu; Lanqun Mao; Yadong Li

doi:10.1039/c8cc08116f

A single-atom Fe-N₄ catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection

Wenjie Ma
, Junjie Mao
, Xiaoti Yang
, Cong Pan
, Wenxing Chen
, Ming Wang
, Ping Yu
, Lanqun Mao^*
, Yadong Li

^*Corresponding author for this work

School of Material Science and Engineering

Research output: Contribution to journal › Article › peer-review

212 Citations (Scopus)

Abstract

Atomically dispersed Fe-N₄ sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.

Original language	English
Pages (from-to)	159-162
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	2
DOIs	https://doi.org/10.1039/c8cc08116f
Publication status	Published - 2019

Access to Document

10.1039/c8cc08116f

Cite this

@article{489060cd7e0440029d08a2df5eae9b27,

title = "A single-atom Fe-N4 catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection",

abstract = "Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.",

author = "Wenjie Ma and Junjie Mao and Xiaoti Yang and Cong Pan and Wenxing Chen and Ming Wang and Ping Yu and Lanqun Mao and Yadong Li",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c8cc08116f",

language = "English",

volume = "55",

pages = "159--162",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "2",

}

TY - JOUR

T1 - A single-atom Fe-N4 catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection

AU - Ma, Wenjie

AU - Mao, Junjie

AU - Yang, Xiaoti

AU - Pan, Cong

AU - Chen, Wenxing

AU - Wang, Ming

AU - Yu, Ping

AU - Mao, Lanqun

AU - Li, Yadong

PY - 2019

Y1 - 2019

N2 - Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.

AB - Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.

UR - https://www.scopus.com/pages/publications/85058884694

U2 - 10.1039/c8cc08116f

DO - 10.1039/c8cc08116f

M3 - Article

C2 - 30465670

AN - SCOPUS:85058884694

SN - 1359-7345

VL - 55

SP - 159

EP - 162

JO - Chemical Communications

JF - Chemical Communications

IS - 2

ER -

A single-atom Fe-N₄ catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection

Abstract

Access to Document

Other files and links

Fingerprint

Cite this