@inproceedings{01be01dd3db046328736e41dc3099cd7,
title = "A novel method to enhance sensitivity in HPLC detection",
abstract = "The peak compression effect induced by velocity difference has been theoretically and experimentally established. L-tryptophan and 2-nitrophenol were used as model compounds. The peak compression of L-tryptophan and 2-nitrophenol was obtained by the difference of its migration velocity along the column induced by the adjustment of composition of mobile phase. A compression of analytes peak and reduced tailing was observed. Under optimum compression condition, 17-fold and 5.9-fold improvement in the detection sensitivity was obtained compared to elution under non-compressed conditions for L-tryptophan and 2-nitrophenol, respectively.",
keywords = "Detection, HPLC, Sensitivity",
author = "Yuxia Wei and Shengyuan Xiao and Xiaoling Mu and Yong Zhu and Gaofei Hu and Yulin Deng and Xinlin Yang",
year = "2007",
doi = "10.1109/ICCME.2007.4382052",
language = "English",
isbn = "1424410789",
series = "2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007",
pages = "1770--1774",
booktitle = "2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007",
note = "2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007 ; Conference date: 23-05-2007 Through 27-05-2007",
}