A novel catalytic application of heteropolyacids: chemical transformation of major ginsenosides into rare ginsenosides exemplified by Rg1

Jie Cao; Chang Liu; Qianqian Wang; Yuze Li; Qing Yu

doi:10.1007/s11426-016-0439-6

A novel catalytic application of heteropolyacids: chemical transformation of major ginsenosides into rare ginsenosides exemplified by R_g1

Jie Cao^*
, Chang Liu
, Qianqian Wang
, Yuze Li
, Qing Yu

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

High performance liquid chromatography coupled with quadruple-time-of-flight mass spectrometry (HPLC-Q-TOF-MS) method was developed for analyzing the hydrolytic mixtures of ginsenoside R_g1 in acidic conditions (pH 3). Three catalysts, a heteropolyacid (H₄SiW₁₂O₄₀, SiW₁₂ for short), its complex with γ-CD (SiW₁₂/γ-CD for short) and formic acid, were used for comparison. The chemical transformation products were identified based on the accurate mass measurement and the fragment ions obtained from tandem mass spectrometry. It was concluded that the catalytic efficiency of SiW₁₂ (≈SiW₁₂/γ-CD) is ca. 410 times higher than that of formic acid, thus becoming the most efficient catalyst for chemical transformations of ginsenosides.

Original language	English
Pages (from-to)	748-753
Number of pages	6
Journal	Science China Chemistry
Volume	60
Issue number	6
DOIs	https://doi.org/10.1007/s11426-016-0439-6
Publication status	Published - 1 Jun 2017

Keywords

HPLC-Q-TOF-MS
ginsenoside R
heteropolyacid
hydrolysis

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10.1007/s11426-016-0439-6

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title = "A novel catalytic application of heteropolyacids: chemical transformation of major ginsenosides into rare ginsenosides exemplified by Rg1",

abstract = "High performance liquid chromatography coupled with quadruple-time-of-flight mass spectrometry (HPLC-Q-TOF-MS) method was developed for analyzing the hydrolytic mixtures of ginsenoside Rg1 in acidic conditions (pH 3). Three catalysts, a heteropolyacid (H4SiW12O40, SiW12 for short), its complex with γ-CD (SiW12/γ-CD for short) and formic acid, were used for comparison. The chemical transformation products were identified based on the accurate mass measurement and the fragment ions obtained from tandem mass spectrometry. It was concluded that the catalytic efficiency of SiW12 (≈SiW12/γ-CD) is ca. 410 times higher than that of formic acid, thus becoming the most efficient catalyst for chemical transformations of ginsenosides.",

keywords = "HPLC-Q-TOF-MS, ginsenoside R, heteropolyacid, hydrolysis",

author = "Jie Cao and Chang Liu and Qianqian Wang and Yuze Li and Qing Yu",

note = "Publisher Copyright: {\textcopyright} 2017, Science China Press and Springer-Verlag Berlin Heidelberg.",

year = "2017",

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doi = "10.1007/s11426-016-0439-6",

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TY - JOUR

T1 - A novel catalytic application of heteropolyacids

T2 - chemical transformation of major ginsenosides into rare ginsenosides exemplified by Rg1

AU - Cao, Jie

AU - Liu, Chang

AU - Wang, Qianqian

AU - Li, Yuze

AU - Yu, Qing

PY - 2017/6/1

Y1 - 2017/6/1

N2 - High performance liquid chromatography coupled with quadruple-time-of-flight mass spectrometry (HPLC-Q-TOF-MS) method was developed for analyzing the hydrolytic mixtures of ginsenoside Rg1 in acidic conditions (pH 3). Three catalysts, a heteropolyacid (H4SiW12O40, SiW12 for short), its complex with γ-CD (SiW12/γ-CD for short) and formic acid, were used for comparison. The chemical transformation products were identified based on the accurate mass measurement and the fragment ions obtained from tandem mass spectrometry. It was concluded that the catalytic efficiency of SiW12 (≈SiW12/γ-CD) is ca. 410 times higher than that of formic acid, thus becoming the most efficient catalyst for chemical transformations of ginsenosides.

AB - High performance liquid chromatography coupled with quadruple-time-of-flight mass spectrometry (HPLC-Q-TOF-MS) method was developed for analyzing the hydrolytic mixtures of ginsenoside Rg1 in acidic conditions (pH 3). Three catalysts, a heteropolyacid (H4SiW12O40, SiW12 for short), its complex with γ-CD (SiW12/γ-CD for short) and formic acid, were used for comparison. The chemical transformation products were identified based on the accurate mass measurement and the fragment ions obtained from tandem mass spectrometry. It was concluded that the catalytic efficiency of SiW12 (≈SiW12/γ-CD) is ca. 410 times higher than that of formic acid, thus becoming the most efficient catalyst for chemical transformations of ginsenosides.

KW - HPLC-Q-TOF-MS

KW - ginsenoside R

KW - heteropolyacid

KW - hydrolysis

UR - https://www.scopus.com/pages/publications/85015867607

U2 - 10.1007/s11426-016-0439-6

DO - 10.1007/s11426-016-0439-6

M3 - Article

AN - SCOPUS:85015867607

SN - 1674-7291

VL - 60

SP - 748

EP - 753

JO - Science China Chemistry

JF - Science China Chemistry

IS - 6

ER -

A novel catalytic application of heteropolyacids: chemical transformation of major ginsenosides into rare ginsenosides exemplified by R_g1

Abstract

Keywords

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