A novel broadband Raman endoscopy for in vivo diagnosis of intestinal metaplasia in the stomach

  • Kan Lin
  • , Mads Sylvest Bergholt
  • , Jianfeng Wang
  • , Wei Zheng
  • , Hongzhi Xu
  • , Jian Lin Ren
  • , Khek Yu Ho
  • , Ming Teh
  • , Khay Guan Yeoh
  • , Zhiwei Huang*
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We report a novel simultaneous fingerprint (FP) and high-wavenumber (HW) fiber-optic Raman spectroscopy developed for in vivo diagnosis of intestinal metaplasia (IM) in the stomach under wide-field endoscopic imaging. The FP/HW Raman endoscopy technique was performed to differentiate IM from normal tissues with sensitivity of 89% and specificity of 83%. This study shows the great potential of the FP/HW Raman endoscopic technique for early diagnosis of non-neoplastic gastric disease in vivo during routine endoscopic examination.

Original languageEnglish
Title of host publicationAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII
EditorsAnita Mahadevan-Jansen, Tuan Vo-Dinh, Warren S. Grundfest
PublisherSPIE
ISBN (Electronic)9781628414035
DOIs
Publication statusPublished - 2015
Externally publishedYes
EventAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII - San Francisco, United States
Duration: 8 Feb 201510 Feb 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9313
ISSN (Print)1605-7422

Conference

ConferenceAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII
Country/TerritoryUnited States
CitySan Francisco
Period8/02/1510/02/15

Keywords

  • Raman spectroscopy
  • endoscopy
  • fingerprint
  • gastric intestinal metaplasia
  • high-wavenumber

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