A mononuclear manganese(II) Complex demonstrates a strategy to simultaneously image and treat oxidative stress

Meng Yu; Stephen L. Ambrose; Zachary L. Whaley; Sanjun Fan; John D. Gorden; Ronald J. Beyers; Dean D. Schwartz; Christian R. Goldsmith

doi:10.1021/ja507034d

A mononuclear manganese(II) Complex demonstrates a strategy to simultaneously image and treat oxidative stress

Meng Yu
, Stephen L. Ambrose
, Zachary L. Whaley
, Sanjun Fan
, John D. Gorden
, Ronald J. Beyers
, Dean D. Schwartz
, Christian R. Goldsmith^*

^*Corresponding author for this work

Auburn University

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

A manganese(II) complex with a ligand containing an oxidizable quinol group serves as a turn-on sensor for H₂O₂. Upon oxidation, the relaxivity of the complex in buffered water increases by 0.8 mM^-1 s^-1, providing a signal that can be detected and quantified by magnetic resonance imaging. The complex also serves as a potent antioxidant, suggesting that this and related complexes have the potential to concurrently visualize and alleviate oxidative stress.

Original language	English
Pages (from-to)	12837-12839
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	136
Issue number	37
DOIs	https://doi.org/10.1021/ja507034d
Publication status	Published - 17 Sept 2014
Externally published	Yes

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10.1021/ja507034d

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abstract = "A manganese(II) complex with a ligand containing an oxidizable quinol group serves as a turn-on sensor for H2O2. Upon oxidation, the relaxivity of the complex in buffered water increases by 0.8 mM-1 s-1, providing a signal that can be detected and quantified by magnetic resonance imaging. The complex also serves as a potent antioxidant, suggesting that this and related complexes have the potential to concurrently visualize and alleviate oxidative stress.",

author = "Meng Yu and Ambrose, \{Stephen L.\} and Whaley, \{Zachary L.\} and Sanjun Fan and Gorden, \{John D.\} and Beyers, \{Ronald J.\} and Schwartz, \{Dean D.\} and Goldsmith, \{Christian R.\}",

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AU - Fan, Sanjun

AU - Gorden, John D.

AU - Beyers, Ronald J.

AU - Schwartz, Dean D.

AU - Goldsmith, Christian R.

PY - 2014/9/17

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AB - A manganese(II) complex with a ligand containing an oxidizable quinol group serves as a turn-on sensor for H2O2. Upon oxidation, the relaxivity of the complex in buffered water increases by 0.8 mM-1 s-1, providing a signal that can be detected and quantified by magnetic resonance imaging. The complex also serves as a potent antioxidant, suggesting that this and related complexes have the potential to concurrently visualize and alleviate oxidative stress.

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DO - 10.1021/ja507034d

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A mononuclear manganese(II) Complex demonstrates a strategy to simultaneously image and treat oxidative stress

Abstract

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