A highly selective wavelength-ratiometric and colorimetric probe for cysteine

Xiaodan Zeng; Xiaoling Zhang; Baocun Zhu; Hongying Jia; Yamin Li

doi:10.1016/j.dyepig.2011.10.013

A highly selective wavelength-ratiometric and colorimetric probe for cysteine

Xiaodan Zeng, Xiaoling Zhang^*, Baocun Zhu, Hongying Jia, Yamin Li

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Based on the nucleophilic aromatic substitution reaction mechanism, a new highly selective probe for cysteine (Cys), N-butyl-4-bromo-3-nitro-1,8- naphthalimide (1), was designed and synthesized. The probe displayed a remarkable (58 nm) red-shift in the absorption spectra and the color changes from colorless to yellow upon reaction with Cys. The probe could detect Cys quantitatively in the range of 0-0.9 mM by both normal and ratiometric absorption spectrometry methods. Moreover, 1 could also serve as a "naked-eye" probe for Cys with a minimum detectable concentration of approximately 50 μM.

Original language	English
Pages (from-to)	10-15
Number of pages	6
Journal	Dyes and Pigments
Volume	94
Issue number	1
DOIs	https://doi.org/10.1016/j.dyepig.2011.10.013
Publication status	Published - Jul 2012

Keywords

Colorimetric
Cysteine
Naphthalimide
Nucleophilic aromatic substitution
Probe
Ratiometric

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10.1016/j.dyepig.2011.10.013

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title = "A highly selective wavelength-ratiometric and colorimetric probe for cysteine",

abstract = "Based on the nucleophilic aromatic substitution reaction mechanism, a new highly selective probe for cysteine (Cys), N-butyl-4-bromo-3-nitro-1,8- naphthalimide (1), was designed and synthesized. The probe displayed a remarkable (58 nm) red-shift in the absorption spectra and the color changes from colorless to yellow upon reaction with Cys. The probe could detect Cys quantitatively in the range of 0-0.9 mM by both normal and ratiometric absorption spectrometry methods. Moreover, 1 could also serve as a {"}naked-eye{"} probe for Cys with a minimum detectable concentration of approximately 50 μM.",

keywords = "Colorimetric, Cysteine, Naphthalimide, Nucleophilic aromatic substitution, Probe, Ratiometric",

author = "Xiaodan Zeng and Xiaoling Zhang and Baocun Zhu and Hongying Jia and Yamin Li",

year = "2012",

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doi = "10.1016/j.dyepig.2011.10.013",

language = "English",

volume = "94",

pages = "10--15",

journal = "Dyes and Pigments",

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TY - JOUR

T1 - A highly selective wavelength-ratiometric and colorimetric probe for cysteine

AU - Zeng, Xiaodan

AU - Zhang, Xiaoling

AU - Zhu, Baocun

AU - Jia, Hongying

AU - Li, Yamin

PY - 2012/7

Y1 - 2012/7

N2 - Based on the nucleophilic aromatic substitution reaction mechanism, a new highly selective probe for cysteine (Cys), N-butyl-4-bromo-3-nitro-1,8- naphthalimide (1), was designed and synthesized. The probe displayed a remarkable (58 nm) red-shift in the absorption spectra and the color changes from colorless to yellow upon reaction with Cys. The probe could detect Cys quantitatively in the range of 0-0.9 mM by both normal and ratiometric absorption spectrometry methods. Moreover, 1 could also serve as a "naked-eye" probe for Cys with a minimum detectable concentration of approximately 50 μM.

AB - Based on the nucleophilic aromatic substitution reaction mechanism, a new highly selective probe for cysteine (Cys), N-butyl-4-bromo-3-nitro-1,8- naphthalimide (1), was designed and synthesized. The probe displayed a remarkable (58 nm) red-shift in the absorption spectra and the color changes from colorless to yellow upon reaction with Cys. The probe could detect Cys quantitatively in the range of 0-0.9 mM by both normal and ratiometric absorption spectrometry methods. Moreover, 1 could also serve as a "naked-eye" probe for Cys with a minimum detectable concentration of approximately 50 μM.

KW - Colorimetric

KW - Cysteine

KW - Naphthalimide

KW - Nucleophilic aromatic substitution

KW - Probe

KW - Ratiometric

UR - https://www.scopus.com/pages/publications/84055217360

U2 - 10.1016/j.dyepig.2011.10.013

DO - 10.1016/j.dyepig.2011.10.013

M3 - Article

AN - SCOPUS:84055217360

SN - 0143-7208

VL - 94

SP - 10

EP - 15

JO - Dyes and Pigments

JF - Dyes and Pigments

IS - 1

ER -

A highly selective wavelength-ratiometric and colorimetric probe for cysteine

Abstract

Keywords

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