Abstract
Binding with distinction: Photo-cross-linking followed by the complementary use of ESI and MALDI mass spectrometric techniques yielded the interaction sites of three prototypical amphipathic transcriptional activators (represented by different-colored helices in the picture) with the coactivator Med15. Investigation of the functional relevance of these sites in yeast revealed overlapping yet distinct binding patterns for the activators investigated.
| Original language | English |
|---|---|
| Pages (from-to) | 7021-7024 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 48 |
| Issue number | 38 |
| DOIs | |
| Publication status | Published - 7 Sept 2009 |
| Externally published | Yes |
Keywords
- Coactivator binding sites
- Cross-linking
- Mass spectrometry
- Photochemistry
- Transcriptional activators
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