A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation

Jiechao Ge; Minhuan Lan; Bingjiang Zhou; Weimin Liu; Liang Guo; Hui Wang; Qingyan Jia; Guangle Niu; Xing Huang; Hangyue Zhou; Xiangmin Meng; Pengfei Wang; Chun Sing Lee; Wenjun Zhang; Xiaodong Han

doi:10.1038/ncomms5596

A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation

Jiechao Ge, Minhuan Lan, Bingjiang Zhou, Weimin Liu, Liang Guo, Hui Wang, Qingyan Jia, Guangle Niu, Xing Huang, Hangyue Zhou, Xiangmin Meng, Pengfei Wang^*, Chun Sing Lee, Wenjun Zhang, Xiaodong Han

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1269 Citations (Scopus)

Abstract

Clinical applications of current photodynamic therapy (PDT) agents are often limited by their low singlet oxygen (1 O 2) quantum yields, as well as by photobleaching and poor biocompatibility. Here we present a new PDT agent based on graphene quantum dots (GQDs) that can produce 1 O 2 via a multistate sensitization process, resulting in a quantum yield of ∼1.3, the highest reported for PDT agents. The GQDs also exhibit a broad absorption band spanning the UV region and the entire visible region and a strong deep-red emission. Through in vitro and in vivo studies, we demonstrate that GQDs can be used as PDT agents, simultaneously allowing imaging and providing a highly efficient cancer therapy. The present work may lead to a new generation of carbon-based nanomaterial PDT agents with overall performance superior to conventional agents in terms of 1 O 2 quantum yield, water dispersibility, photo-and pH-stability, and biocompatibility.

Original language	English
Article number	4596
Journal	Nature Communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms5596
Publication status	Published - 8 Aug 2014
Externally published	Yes

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title = "A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation",

abstract = "Clinical applications of current photodynamic therapy (PDT) agents are often limited by their low singlet oxygen (1 O 2) quantum yields, as well as by photobleaching and poor biocompatibility. Here we present a new PDT agent based on graphene quantum dots (GQDs) that can produce 1 O 2 via a multistate sensitization process, resulting in a quantum yield of ∼1.3, the highest reported for PDT agents. The GQDs also exhibit a broad absorption band spanning the UV region and the entire visible region and a strong deep-red emission. Through in vitro and in vivo studies, we demonstrate that GQDs can be used as PDT agents, simultaneously allowing imaging and providing a highly efficient cancer therapy. The present work may lead to a new generation of carbon-based nanomaterial PDT agents with overall performance superior to conventional agents in terms of 1 O 2 quantum yield, water dispersibility, photo-and pH-stability, and biocompatibility.",

author = "Jiechao Ge and Minhuan Lan and Bingjiang Zhou and Weimin Liu and Liang Guo and Hui Wang and Qingyan Jia and Guangle Niu and Xing Huang and Hangyue Zhou and Xiangmin Meng and Pengfei Wang and Lee, {Chun Sing} and Wenjun Zhang and Xiaodong Han",

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T1 - A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation

AU - Ge, Jiechao

AU - Lan, Minhuan

AU - Zhou, Bingjiang

AU - Liu, Weimin

AU - Guo, Liang

AU - Wang, Hui

AU - Jia, Qingyan

AU - Niu, Guangle

AU - Huang, Xing

AU - Zhou, Hangyue

AU - Meng, Xiangmin

AU - Wang, Pengfei

AU - Lee, Chun Sing

AU - Zhang, Wenjun

AU - Han, Xiaodong

PY - 2014/8/8

Y1 - 2014/8/8

N2 - Clinical applications of current photodynamic therapy (PDT) agents are often limited by their low singlet oxygen (1 O 2) quantum yields, as well as by photobleaching and poor biocompatibility. Here we present a new PDT agent based on graphene quantum dots (GQDs) that can produce 1 O 2 via a multistate sensitization process, resulting in a quantum yield of ∼1.3, the highest reported for PDT agents. The GQDs also exhibit a broad absorption band spanning the UV region and the entire visible region and a strong deep-red emission. Through in vitro and in vivo studies, we demonstrate that GQDs can be used as PDT agents, simultaneously allowing imaging and providing a highly efficient cancer therapy. The present work may lead to a new generation of carbon-based nanomaterial PDT agents with overall performance superior to conventional agents in terms of 1 O 2 quantum yield, water dispersibility, photo-and pH-stability, and biocompatibility.

AB - Clinical applications of current photodynamic therapy (PDT) agents are often limited by their low singlet oxygen (1 O 2) quantum yields, as well as by photobleaching and poor biocompatibility. Here we present a new PDT agent based on graphene quantum dots (GQDs) that can produce 1 O 2 via a multistate sensitization process, resulting in a quantum yield of ∼1.3, the highest reported for PDT agents. The GQDs also exhibit a broad absorption band spanning the UV region and the entire visible region and a strong deep-red emission. Through in vitro and in vivo studies, we demonstrate that GQDs can be used as PDT agents, simultaneously allowing imaging and providing a highly efficient cancer therapy. The present work may lead to a new generation of carbon-based nanomaterial PDT agents with overall performance superior to conventional agents in terms of 1 O 2 quantum yield, water dispersibility, photo-and pH-stability, and biocompatibility.

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SN - 2041-1723

VL - 5

JO - Nature Communications

JF - Nature Communications

M1 - 4596

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A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation

Abstract

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