A global phenomenological model of ischemic stroke with stress on spreading depressions

G. Chapuisat; M. A. Dronne; E. Grenier; M. Hommel; H. Gilquin; J. P. Boissel

doi:10.1016/j.pbiomolbio.2007.10.004

A global phenomenological model of ischemic stroke with stress on spreading depressions

G. Chapuisat^*
, M. A. Dronne
, E. Grenier
, M. Hommel
, H. Gilquin
, J. P. Boissel

^*Corresponding author for this work

CNRS
Institut de Médecine Théorique
Universite Claude Bernard Lyon 1
École normale supérieure de Lyon
CHU de Grenoble
EMET
Centre Léon Bérard

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

Abstract

In this paper, we establish a new global phenomenological model of ischemic stroke. It takes into account local ischemia, energy reduction, propagation of spreading depressions (SD), damages to the cells and cellular death by apoptosis or necrosis. The spatial diffusion of the ions in the extracellular space which triggers the propagation of SD is a central point here. First we expose the various biological hypotheses that we have made in this model, and then we explain how to determine the parameters and solve the system of equations that we obtain. Next we present some results of this model: we simulate a KCl injection and then a local ischemia. Finally we discuss results and propose some improvements for this model.

Original language	English
Pages (from-to)	4-27
Number of pages	24
Journal	Progress in Biophysics and Molecular Biology
Volume	97
Issue number	1
DOIs	https://doi.org/10.1016/j.pbiomolbio.2007.10.004
Publication status	Published - May 2008
Externally published	Yes

Keywords

Ischemic stroke
Modelling
Parameters value
Spreading depression

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title = "A global phenomenological model of ischemic stroke with stress on spreading depressions",

abstract = "In this paper, we establish a new global phenomenological model of ischemic stroke. It takes into account local ischemia, energy reduction, propagation of spreading depressions (SD), damages to the cells and cellular death by apoptosis or necrosis. The spatial diffusion of the ions in the extracellular space which triggers the propagation of SD is a central point here. First we expose the various biological hypotheses that we have made in this model, and then we explain how to determine the parameters and solve the system of equations that we obtain. Next we present some results of this model: we simulate a KCl injection and then a local ischemia. Finally we discuss results and propose some improvements for this model.",

keywords = "Ischemic stroke, Modelling, Parameters value, Spreading depression",

author = "G. Chapuisat and Dronne, \{M. A.\} and E. Grenier and M. Hommel and H. Gilquin and Boissel, \{J. P.\}",

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T1 - A global phenomenological model of ischemic stroke with stress on spreading depressions

AU - Chapuisat, G.

AU - Dronne, M. A.

AU - Grenier, E.

AU - Hommel, M.

AU - Gilquin, H.

AU - Boissel, J. P.

PY - 2008/5

Y1 - 2008/5

N2 - In this paper, we establish a new global phenomenological model of ischemic stroke. It takes into account local ischemia, energy reduction, propagation of spreading depressions (SD), damages to the cells and cellular death by apoptosis or necrosis. The spatial diffusion of the ions in the extracellular space which triggers the propagation of SD is a central point here. First we expose the various biological hypotheses that we have made in this model, and then we explain how to determine the parameters and solve the system of equations that we obtain. Next we present some results of this model: we simulate a KCl injection and then a local ischemia. Finally we discuss results and propose some improvements for this model.

AB - In this paper, we establish a new global phenomenological model of ischemic stroke. It takes into account local ischemia, energy reduction, propagation of spreading depressions (SD), damages to the cells and cellular death by apoptosis or necrosis. The spatial diffusion of the ions in the extracellular space which triggers the propagation of SD is a central point here. First we expose the various biological hypotheses that we have made in this model, and then we explain how to determine the parameters and solve the system of equations that we obtain. Next we present some results of this model: we simulate a KCl injection and then a local ischemia. Finally we discuss results and propose some improvements for this model.

KW - Ischemic stroke

KW - Modelling

KW - Parameters value

KW - Spreading depression

UR - https://www.scopus.com/pages/publications/43049173396

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DO - 10.1016/j.pbiomolbio.2007.10.004

M3 - Review article

C2 - 18063019

AN - SCOPUS:43049173396

SN - 0079-6107

VL - 97

SP - 4

EP - 27

JO - Progress in Biophysics and Molecular Biology

JF - Progress in Biophysics and Molecular Biology

IS - 1

ER -

A global phenomenological model of ischemic stroke with stress on spreading depressions

Abstract

Keywords

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