A CoII complex for19F MRI-based detection of reactive oxygen species

Meng Yu; Da Xie; Khanh P. Phan; José S. Enriquez; Jeffrey J. Luci; Emily L. Que

doi:10.1039/c6cc08207f

A Co^II complex for¹⁹F MRI-based detection of reactive oxygen species

Meng Yu
, Da Xie
, Khanh P. Phan
, José S. Enriquez
, Jeffrey J. Luci
, Emily L. Que^*

^*Corresponding author for this work

University of Texas at Austin

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

A fluorinated, air-stable cobalt(ii) complex serves as a turn-on¹⁹F magnetic resonance imaging (MRI) tracer for reactive oxygen species including H₂O₂. Upon oxidation with H₂O₂, the complex converts from paramagnetic high spin Co^II to diamagnetic low spin Co^III resulting in a chemical shift change and enhancement in¹⁹F NMR signal. Further, the oxidation can be reversed in the presence of reductant Na₂S₂O₄. The turn-on response is demonstrated by¹⁹F MRI, characterized by a ∼2-3 fold enhancement in signal.

Original language	English
Pages (from-to)	13885-13888
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	96
DOIs	https://doi.org/10.1039/c6cc08207f
Publication status	Published - 2016
Externally published	Yes

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title = "A CoII complex for19F MRI-based detection of reactive oxygen species",

abstract = "A fluorinated, air-stable cobalt(ii) complex serves as a turn-on19F magnetic resonance imaging (MRI) tracer for reactive oxygen species including H2O2. Upon oxidation with H2O2, the complex converts from paramagnetic high spin CoII to diamagnetic low spin CoIII resulting in a chemical shift change and enhancement in19F NMR signal. Further, the oxidation can be reversed in the presence of reductant Na2S2O4. The turn-on response is demonstrated by19F MRI, characterized by a ∼2-3 fold enhancement in signal.",

author = "Meng Yu and Da Xie and Phan, \{Khanh P.\} and Enriquez, \{Jos{\'e} S.\} and Luci, \{Jeffrey J.\} and Que, \{Emily L.\}",

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language = "English",

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T1 - A CoII complex for19F MRI-based detection of reactive oxygen species

AU - Yu, Meng

AU - Xie, Da

AU - Phan, Khanh P.

AU - Enriquez, José S.

AU - Luci, Jeffrey J.

AU - Que, Emily L.

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2016

Y1 - 2016

N2 - A fluorinated, air-stable cobalt(ii) complex serves as a turn-on19F magnetic resonance imaging (MRI) tracer for reactive oxygen species including H2O2. Upon oxidation with H2O2, the complex converts from paramagnetic high spin CoII to diamagnetic low spin CoIII resulting in a chemical shift change and enhancement in19F NMR signal. Further, the oxidation can be reversed in the presence of reductant Na2S2O4. The turn-on response is demonstrated by19F MRI, characterized by a ∼2-3 fold enhancement in signal.

AB - A fluorinated, air-stable cobalt(ii) complex serves as a turn-on19F magnetic resonance imaging (MRI) tracer for reactive oxygen species including H2O2. Upon oxidation with H2O2, the complex converts from paramagnetic high spin CoII to diamagnetic low spin CoIII resulting in a chemical shift change and enhancement in19F NMR signal. Further, the oxidation can be reversed in the presence of reductant Na2S2O4. The turn-on response is demonstrated by19F MRI, characterized by a ∼2-3 fold enhancement in signal.

UR - https://www.scopus.com/pages/publications/84998692957

U2 - 10.1039/c6cc08207f

DO - 10.1039/c6cc08207f

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AN - SCOPUS:84998692957

SN - 1359-7345

VL - 52

SP - 13885

EP - 13888

JO - Chemical Communications

JF - Chemical Communications

IS - 96

ER -

A Co^II complex for¹⁹F MRI-based detection of reactive oxygen species

Abstract

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