A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement

Xiaolong Fu; Si Wang; Yunhao Wu; Yu Sun; Wenwen Liu; Xin Xi; Geng Lin Li; Ke Liu; Wei Yuan; Fangyi Chen; Hongyang Wang; Tao Yang; Yuhe Liu; Jialin Zheng; Haibo Shi; Jing Qu; Xiaowei Chen; Limin Suo; Yideng Huang; Xinbo Xu; Xuxia Tang; Xiaojun Li; Lei Xu; Xia Gao; Lisheng Yu; Yilai Shu; Weiqi Zhang; Jinpeng Sun; Huijun Yuan; Shusheng Gong; Wenyan Li; Xiulan Ma; Dingjun Zha; Jiangang Gao; Huawei Li; Zuhong He; Guang Hui Liu; Gang Pei; Weijia Kong; Haibo Wang; Renjie Chai

doi:10.1093/lifemedi/lnaf011

A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement

Xiaolong Fu, Si Wang, Yunhao Wu, Yu Sun, Wenwen Liu, Xin Xi^*, Geng Lin Li^*, Ke Liu^*, Wei Yuan^*, Fangyi Chen^*, Hongyang Wang^*, Tao Yang^*, Yuhe Liu^*, Jialin Zheng^*, Haibo Shi^*, Jing Qu^*, Xiaowei Chen^*, Limin Suo^*, Yideng Huang^*, Xinbo Xu^*Xuxia Tang^*, Xiaojun Li^*, Lei Xu^*, Xia Gao^*, Lisheng Yu^*, Yilai Shu^*, Weiqi Zhang^*, Jinpeng Sun^*, Huijun Yuan^*, Shusheng Gong^*, Wenyan Li^*, Xiulan Ma^*, Dingjun Zha^*, Jiangang Gao^*, Huawei Li^*, Zuhong He^*, Guang Hui Liu^*, Gang Pei^*, Weijia Kong^*, Haibo Wang^*, Renjie Chai^*

^*Corresponding author for this work

School of Life Science

Research output: Contribution to journal › Article › peer-review

Abstract

Hearing is one of the most vital sensory functions in human beings and a crucial means of perceiving and acquiring information from the natural environment. The advancement of human society is closely linked to the development of language, with hearing serving as the foundation for verbal communication. As individuals age, the deterioration of the auditory system becomes a significant factor contributing to sensory impairments in the elderly. In addition to hearing loss, the aging of the auditory system is also associated with cognitive decline and psychosocial disorders, which severely impact the quality of life for older adults. Currently, there are no effective treatments or interventions available for addressing the aging of the auditory system. Therefore, identifying biomarkers of the auditory system aging is of great significance. The Aging Biomarker Consortium of China has conducted a comprehensive evaluation of aging biomarkers in the auditory system, focusing on three dimensions: morphological, functional, and humoral biomarkers. This initiative aims to establish a foundation for assessing the degree of aging in the auditory system and to promote the management of auditory health in an aging society, ultimately enhancing the auditory health of the elderly population both in China and globally.

Original language	English
Article number	lnaf011
Journal	Life Medicine
Volume	4
Issue number	1
DOIs	https://doi.org/10.1093/lifemedi/lnaf011
Publication status	Published - 1 Feb 2025

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10.1093/lifemedi/lnaf011

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Fu, X., Wang, S., Wu, Y., Sun, Y., Liu, W., Xi, X., Li, G. L., Liu, K., Yuan, W., Chen, F., Wang, H., Yang, T., Liu, Y., Zheng, J., Shi, H., Qu, J., Chen, X., Suo, L., Huang, Y., ... Chai, R. (2025). A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement. Life Medicine, 4(1), Article lnaf011. https://doi.org/10.1093/lifemedi/lnaf011

@article{02ae1c94c1344469afc5c449141c97f8,

title = "A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement",

abstract = "Hearing is one of the most vital sensory functions in human beings and a crucial means of perceiving and acquiring information from the natural environment. The advancement of human society is closely linked to the development of language, with hearing serving as the foundation for verbal communication. As individuals age, the deterioration of the auditory system becomes a significant factor contributing to sensory impairments in the elderly. In addition to hearing loss, the aging of the auditory system is also associated with cognitive decline and psychosocial disorders, which severely impact the quality of life for older adults. Currently, there are no effective treatments or interventions available for addressing the aging of the auditory system. Therefore, identifying biomarkers of the auditory system aging is of great significance. The Aging Biomarker Consortium of China has conducted a comprehensive evaluation of aging biomarkers in the auditory system, focusing on three dimensions: morphological, functional, and humoral biomarkers. This initiative aims to establish a foundation for assessing the degree of aging in the auditory system and to promote the management of auditory health in an aging society, ultimately enhancing the auditory health of the elderly population both in China and globally.",

author = "Xiaolong Fu and Si Wang and Yunhao Wu and Yu Sun and Wenwen Liu and Xin Xi and Li, {Geng Lin} and Ke Liu and Wei Yuan and Fangyi Chen and Hongyang Wang and Tao Yang and Yuhe Liu and Jialin Zheng and Haibo Shi and Jing Qu and Xiaowei Chen and Limin Suo and Yideng Huang and Xinbo Xu and Xuxia Tang and Xiaojun Li and Lei Xu and Xia Gao and Lisheng Yu and Yilai Shu and Weiqi Zhang and Jinpeng Sun and Huijun Yuan and Shusheng Gong and Wenyan Li and Xiulan Ma and Dingjun Zha and Jiangang Gao and Huawei Li and Zuhong He and Liu, {Guang Hui} and Gang Pei and Weijia Kong and Haibo Wang and Renjie Chai",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025. Published by Oxford University Press on behalf of Higher Education Press.",

year = "2025",

month = feb,

day = "1",

doi = "10.1093/lifemedi/lnaf011",

language = "English",

volume = "4",

journal = "Life Medicine",

issn = "2755-1733",

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Fu, X, Wang, S, Wu, Y, Sun, Y, Liu, W, Xi, X, Li, GL, Liu, K, Yuan, W, Chen, F, Wang, H, Yang, T, Liu, Y, Zheng, J, Shi, H, Qu, J, Chen, X, Suo, L, Huang, Y, Xu, X, Tang, X, Li, X, Xu, L, Gao, X, Yu, L, Shu, Y, Zhang, W, Sun, J, Yuan, H, Gong, S, Li, W, Ma, X, Zha, D, Gao, J, Li, H, He, Z, Liu, GH, Pei, G, Kong, W, Wang, H & Chai, R 2025, 'A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement', Life Medicine, vol. 4, no. 1, lnaf011. https://doi.org/10.1093/lifemedi/lnaf011

TY - JOUR

T1 - A biomarker framework for auditory system aging

T2 - the Aging Biomarker Consortium consensus statement

AU - Fu, Xiaolong

AU - Wang, Si

AU - Wu, Yunhao

AU - Sun, Yu

AU - Liu, Wenwen

AU - Xi, Xin

AU - Li, Geng Lin

AU - Liu, Ke

AU - Yuan, Wei

AU - Chen, Fangyi

AU - Wang, Hongyang

AU - Yang, Tao

AU - Liu, Yuhe

AU - Zheng, Jialin

AU - Shi, Haibo

AU - Qu, Jing

AU - Chen, Xiaowei

AU - Suo, Limin

AU - Huang, Yideng

AU - Xu, Xinbo

AU - Tang, Xuxia

AU - Li, Xiaojun

AU - Xu, Lei

AU - Gao, Xia

AU - Yu, Lisheng

AU - Shu, Yilai

AU - Zhang, Weiqi

AU - Sun, Jinpeng

AU - Yuan, Huijun

AU - Gong, Shusheng

AU - Li, Wenyan

AU - Ma, Xiulan

AU - Zha, Dingjun

AU - Gao, Jiangang

AU - Li, Huawei

AU - He, Zuhong

AU - Liu, Guang Hui

AU - Pei, Gang

AU - Kong, Weijia

AU - Wang, Haibo

AU - Chai, Renjie

PY - 2025/2/1

Y1 - 2025/2/1

N2 - Hearing is one of the most vital sensory functions in human beings and a crucial means of perceiving and acquiring information from the natural environment. The advancement of human society is closely linked to the development of language, with hearing serving as the foundation for verbal communication. As individuals age, the deterioration of the auditory system becomes a significant factor contributing to sensory impairments in the elderly. In addition to hearing loss, the aging of the auditory system is also associated with cognitive decline and psychosocial disorders, which severely impact the quality of life for older adults. Currently, there are no effective treatments or interventions available for addressing the aging of the auditory system. Therefore, identifying biomarkers of the auditory system aging is of great significance. The Aging Biomarker Consortium of China has conducted a comprehensive evaluation of aging biomarkers in the auditory system, focusing on three dimensions: morphological, functional, and humoral biomarkers. This initiative aims to establish a foundation for assessing the degree of aging in the auditory system and to promote the management of auditory health in an aging society, ultimately enhancing the auditory health of the elderly population both in China and globally.

AB - Hearing is one of the most vital sensory functions in human beings and a crucial means of perceiving and acquiring information from the natural environment. The advancement of human society is closely linked to the development of language, with hearing serving as the foundation for verbal communication. As individuals age, the deterioration of the auditory system becomes a significant factor contributing to sensory impairments in the elderly. In addition to hearing loss, the aging of the auditory system is also associated with cognitive decline and psychosocial disorders, which severely impact the quality of life for older adults. Currently, there are no effective treatments or interventions available for addressing the aging of the auditory system. Therefore, identifying biomarkers of the auditory system aging is of great significance. The Aging Biomarker Consortium of China has conducted a comprehensive evaluation of aging biomarkers in the auditory system, focusing on three dimensions: morphological, functional, and humoral biomarkers. This initiative aims to establish a foundation for assessing the degree of aging in the auditory system and to promote the management of auditory health in an aging society, ultimately enhancing the auditory health of the elderly population both in China and globally.

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U2 - 10.1093/lifemedi/lnaf011

DO - 10.1093/lifemedi/lnaf011

M3 - Article

AN - SCOPUS:105002768070

SN - 2755-1733

VL - 4

JO - Life Medicine

JF - Life Medicine

IS - 1

M1 - lnaf011

ER -

A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement

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