高效叠氮化方法研究进展

Organic azide compounds are a class of multifunctional compounds that are useful precursors for synthesizing a range of therapeutic drugs,bioactive compounds,functional materials,and high-energy compounds. They are widely used in click chemistry and Staudinger reactions. In the past few decades,a large number of synthesis strategies have been developed to prepare structurally diverse organic azides,but not all reactions can be carried out efficiently. As the concept of green chemistry deepens in people’s hearts,traditional azide methods with low safety, universality,and efficiency are gradually being phased out,and the development of new and efficient azide methods is urgent. This review focuses on the efficient synthesis methods for preparing aliphatic azide compounds and azide polymers in recent years. A brief overview of the synthesis of aliphatic azide compounds is provided from the azide strategies of C—C multiple bonds and C—H bonds. The synthesis methods and potential novel synthesis strategies of azide polymers are also discussed,and the future development of azide chemistry is summarized and discussed.