通过仿生矿化修复人体牙齿结构

Dentin hypersensitivity, dental caries, and tooth wear and fracture severely influence human daily life. A lot of strategies have been applied to solve these problems by different researchers. Biomineralization refers to the processes by which organisms form hard tissues (such as teeth, bone, and shells et al.). Generally, these hard tissues are regular, hierarchically structured, and functional organic-inorganic composites which formed by biomacromolecules controlling the nucleation and growth of inorganic minerals. Recently, many researchers mimic the natural development and biomineralization of teeth to regenerate and repair the natural hard dental tissues, which have great importance in biomedical applications. The biomimetic restorative approach can restore the tooth to its natural state in composition, structure, and mechanical properties compared with traditional restoration such as using lasers and organic bonding agents. What’s more, it is harmless, biocompatible, and can combine with antibacterial and anti-fouling properties. Therefore, the biomimetic restorative approach will fundamentally solve these dental problems. Here we review recent progress towards tooth structure, desensitization, remineralization, and its restorative materials.