芽胞杆菌耐受胁迫条件的机制及工业应用

Bacillus, as a highly potential chassis strain, can grow in various industrial and agricultural waste and extreme conditions. They can also produce a variety of industrial products such as food, feed, probiotics, plant growth promoters, enzymes, and bioactive compounds. However, despite their advantages in efficient production and low cost, Bacillus still face several bottlenecks in fermentation production, limiting the full exploitation of their industrial potential. One of the key issues is that the growth and production efficiency during fermentation are easily restricted by various stress conditions, leading to incomplete and inefficient fermentation production. Therefore, exploring the influencing factors and modification strategies of Bacillus stress response, and exploring the relationship between its various metabolic activities and growth traits, can enhance the tolerance of Bacillus to stress and improve their quality and quantity in industrial applications.This article first analyzes the various stress response mechanisms of Bacillus, aiming to further enhance its stress tolerance and to construct a high-efficiency production strain with excellent resistance, and then summarizes the irrational design strategies for screening resistant strains. It also elaborates on the construction methods of stress-resistant gene circuits and high-tolerance microbial chassis. These efforts provide strategies and insights to advance research on stress tolerance mechanisms in Bacillus and expand its industrial applications.