聚集诱导发光材料在药物递送与疾病治疗中的研究进展

Drug delivery systems containing fluorescent probes have the advantage of simultaneous diagnosis and treatment in disease research. Traditional organic fluorescein may exhibit a phenomenon of aggregation caused quenching (ACQ) after aggregation at high concentration. In contrast, it is reported that when a class of fluorescein molecules aggregate in solution, a new phenomenon called aggregation-induced emission (AIE) may occur, because the intramolecular motion is restricted, the non-radiative channel of the molecule is suppressed, and the energy is released in the form of light energy under this circumstance. Drug delivery systems and therapeutic modalities based on AIE fluorescein, termed AIEgen, show promising prospects in detecting and treating life-threatening diseases. This article reviews the research progress of AIE fluorescein in drug delivery, photodynamic and photothermal therapy, and looks forward to the challenges and future directions of research in this field.