材料表面性质调控细胞黏附

Biomaterials aim to achieve tissue regeneration and repair by regulating the interaction between materials and cells. The adhesion determines whether cells could perform the expected biological functions absolutely. Therefore, it is critical for biomaterials to regulate cell adhesion by surface physical and chemical properties, which have aroused more and more attention recently. The physical modification on materials surface usually includes the regulation of surface roughness, morphology, modulus, and porous properties in order to build a suitable environment for cell adhesion. On the other hand, the chemical modifications such as surface charge and hydrophobicity regulation, covalently grafting and encapsulating adhesion-promoting molecules into the surface have made great effort to improve the interaction between the material surface and the cell, which will be capable of promoting cell adhesion. In recent years, a great number of breakthroughs have been accomplished in the field. In addition to covalently graft various adhesion-promoting molecules on the surface, it is reported that the adhesion performance would be significantly promoted by precise control of the sequence of the adhesion-promoting molecules. The sequence modulation represents a new strategy of surface modification, which can greatly enhance cell adhesion without the introduction of more powerful cell-promoting molecules or increasing their density. Besides, the intelligent change of adhesion-promoting and anti-adhesion surface can be accomplished according to the stimuli of external signals, which has been successfully applied in cell sheet tissue engineering and shows promising potential to be put into clinical application. Consequently, the review comprehensively summarizes the influences of material surface properties on cell adhesion by physical and chemical surface modification as well as the regulation of stimuli-responsive surface, the designs of adhesion-promoting surface, the technologies of adhesion-promoting surface preparation, and discusses their prospects.