慢性精神分裂症患者血浆白介素17与糖脂代谢的相关性研究

Background The pathogenesis of schizophrenia is closely related to inflammation, whose stage has a strong link with metabolic level, so the relationship of IL-17, an important early inflammatory promoter, with glycolipid metabolism in schizophrenics is worth studying. Objective: To explore the relationship between plasma IL-17 level and glycolipid metabolism in patients with chronic schizophrenia. Methods; Patients with chronic schizophrenia who met the study criteria were selected from Chaohu Hospital of Anhui Medical University, Hefei Fourth People's Hospital and Maanshan Fourth People's Hospital from April to June 2018.According to the quartile of plasma IL-17 level, they were divided into high IL-17(≥ P₇₅), and low IL-17(<P₇₅) groups. And intergroup differences in the general data, including socio-demographic data, and clinical data 〔partial electronic medical records of hospitalization, glucose and lipid metabolism indices, Positive and Negative Syndrome Scale(PANSS) and its subscale scores〕 were analyzed. The relationships of plasma IL-17 level and glucose and lipid metabolic indices were estimated. The influencing factors of plasma IL-17 level were explored. Results: A total of 327 patients were enrolled, including 82 with high level of IL-17 〔33.20(51.82)ng/L〕 and 245 with low level of IL-17 〔2.69(2.39)ng/L〕.High and low IL-17 groups had no significant differences in sex ratio, distribution of marital status, prevalence of previous or present diabetes, average fasting blood glucose and scale and subscale scores of PANSS, and median age, years of education, duration of chronic schizophrenia, chlorpromazine equivalent, total cholesterol, triglyceride, and low-density lipoprotein(P>0.05), but showed significant differences in average age of onset, high-density lipoprotein(HDL) level, insulin and glucagon levels(P<0.05).Spearman correlation analysis showed that plasma IL-17 level was positively correlated with HDL(rs=0.179, P=0.001) and glucagon levels(rs=0.155, P=0.005).Binary Logistic regression analysis showed that, HDL level〔OR=6.24, 95%CI(2.31, 16.86), P<0.001〕 and insulin level 〔OR=1.05, 95%CI(1.01, 1.10), P=0.021〕 were the influencing factors of plasma IL-17 level. Conclusion: In chronic schizophrenia patients, high plasma IL-17 level was associated with higher levels of insulin, glucagon and HDL, and IL-17 may be associated with glucose and lipid metabolism.