微生物细胞合成植物天然产物的耐受工程研究

Natural products are a class of valuable compounds, with a wide range of types and functions, widely used in medicine, food, chemical industry and other fields. With the development of synthetic biology, microbial cells have shown great potential in the synthesis of plant natural products, providing a new production approach for drug research and development, food science and the cosmetics industry. However, there are still many challenges ahead. Plant natural products have many bactericidal, anti-inflammatory and other pharmacological properties. Excessive production in microbial cells leads to toxic effects on the cells. At the same time, the accumulation of toxic intermediates in the synthesis process will also exacerbate cytotoxicity. It is therefore particularly important to improve the tolerance of microorganisms to plant natural products. In recent years, with the continuous regulation of microbial cell factories, the production of plant natural products has gradually increased, along with the research of microbial cell tolerance. However, there is rarely a systematic summary of the research area. Therefore, this paper aims to provide a comprehensive overview of the research on microbial cell tolerance to plant natural products, focusing on the strategies to improve microbial cell tolerance, the current major challenges, and the prospects for the development of this area.