Xudong Feng

Feng Xudong, Associate Professor (Special Researcher), doctoral supervisor. In 2014, he obtained a doctor's degree in engineering from the University of Auckland (New Zealand). In the same year, he joined the Beijing Institute of Technology as a post-doctoral teacher (his co-supervisor was Professor Li Chun). At present, he is the deputy director of the Institute of Biochemical Engineering and the responsible professor of biochemical engineering in the School of Chemistry and Chemical Engineering. The research field includes biocatalysis and enzyme engineering synthetic biology, and the research content mainly includes the mining, modification and engineering application of key enzymes in the synthesis and modification of plant natural products. In 2019, he was selected into the Beijing Science and Technology New Star Program. He is the young editorial Board member of Frontiers of Chemical Science and Engineering and the editorial board member of Synthetic Biology.

Research areas: (1) Biocatalysis and enzyme engineering; (2) Synthetic biology.
Research direction: The main research content is the mining, engineering transformation and application of key enzymes in the synthesis of plant natural products, and the structure-activity relationship between the structure and function of enzymes is studied by using protein structure analysis and computer simulation technology. By means of protein engineering, the stability, activity and substrate specificity of enzymes were modified to obtain high efficiency enzyme preparations that meet the needs of industrialization. By constructing cell-free catalytic system or microbial cell factory to synthesize plant natural products efficiently, biochemical reaction engineering and metabolic engineering strategies are used to strengthen the biotransformation process and provide theoretical guidance for realizing its industrialization.
At present, there are 4 doctoral students, 8 master students, 2 graduated doctoral students and 6 master students. The team has sufficient funds and a good scientific research atmosphere. Every year, there are 1 doctoral student and 2-3 master's students. Welcome like-minded students to join the team and sublimate themselves through scientific research!

2010.04-2014.06 University of Auckland (New Zealand), Chemical Engineering major, Doctor of Engineering
2007.09-2009.06 Tianjin University, Major in Biochemistry, Master of Engineering
2003.09-2007.07 Hebei University of Technology, Bioengineering, Bachelor of Engineering

2021.07-present Beijing Institute of Technology, School of Chemistry and Chemical Engineering, Associate Professor (Special Researcher)
2017.12-2021.06 Assistant Professor, School of Chemistry and Chemical Engineering, Beijing Institute of Technology
2016.10-2017.11 Assistant Professor, School of Life Sciences, Beijing Institute of Technology
2014.07-2016.09 Beijing Institute of Technology, School of Life Sciences, Faculty postdoctoral (Co-supervisor: Professor Li Chun)

He has presided over 3 projects of National Natural Science Foundation, 2 sub-projects of national key research and development Plan, and 5 projects commissioned by provincial and ministerial level and enterprises, with a total fund of more than 10 million yuan. As first or corresponding author in Biotechnol Adv, Nat Prod Rep, Crit Rev Biotechnol, Biotechnol Bioeng, Green Chem, AIChE J, Appl Environ Microb, J Agr Food Chem, Chem Eng Sci, Bioresource Technol and other mainstream journals published 36 papers, authorized 11 national invention patents, applied for 1 PCT patent. He has made more than 10 reports in academic conferences at home and abroad and won the excellent oral report award twice. I guided students to win iGEM Gold Medal twice and national scholarship for graduate students twice.
Representative papers in recent 5 years:
1. Shichao Ren, Qiuyan Sun, Liang Zhang, Wentao Sun, Yongxing Li, Xudong Feng*, Chun Li*. Sustainable production of rare oleanane-type ginsenoside Ro with an artificial glycosylation pathway in Saccharomyces cerevisiae. Green Chemistry, 2022, 24: 8302-8313.
2. Xing Jian, Chun Li, Xudong Feng*. Strategies for modulating transglycosylation activity, substrate specificity, and product polymerization degree of engineered transglycosylases. Critical Reviews in Biotechnology, 2022, DOI: 10.1080/07388551.2022.2105687. < br > 3. Bo Gao, Bo Yang, Xudong Feng*, Chun Li*. Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products. Natural Product Reports, 2022, 39 (1): 139-162.
4. Mingzhu Liu, Jing Yu, Bo Lv*, Yuhui Hou, Xinhe Liu, Xudong Feng*, Chun Li. Improving the activity and thermostability of GH2 beta -glucuronidases via domain reassembly. Biotechnology and Bioengineering, 2021, 118(5): 1962-1972.
5. Muhammad Akram, Aamir Rasool, Ting An, Xudong Feng*, Chun Li*. Metabolic engineering of Yarrowia lipolytica for liquiritigenin production. Chemical Engineering Science, 2021, 230: 116177.
6. Akram Muhammad, Xudong Feng*, Aamir Rasool, Wentao Sun, Chun Li*. Production of plant natural products through engineered Yarrowia lipolytica. Biotechnology Advances, 2020, 43: 107555.
7. Liang Zhang, Shichao Ren, Xiaofei Liu, Xiaochen Liu, Fang Guo, Wentao Sun, Xudong Feng*, Chun Li*. Mining of UDP-glucosyltransferases in licorice for controllable glycosylation of pentacyclic triterpenoids. Biotechnology and Bioengineering, 2020, 117(12): 3651-3663.
8. Yanan Gao, Liang Zhang, Xudong Feng*, Xiaofei Liu, Fang Guo, Bo Lv, Chun Li*. Galactosylation of monosaccharide derivatives of glycyrrhetinic acid by UDP-glycosyltransferase GmSGT2 from Glycine max. Journal of Agricultural and Food Chemistry, 2020, 68(32): 8580-8588.
9. Xudong Wang, Xudong Feng*, Bo Lv, Anqi Zhou, Yuhui Hou, Chun Li*. Enhanced yeast surface display of β-glucuronidase with dual anchor motifs for high-temperature glycyrrhizin hydrolysis. AIChE Journal, 2019, 65: e16629.
10. Liang Zhang, Yanan Gao, Xiaofei Liu, Fang Guo, Congxuan Ma, Jianhua Liang, Xudong Feng*, Chun Li. Mining of sucrose synthases from Glycyrrhiza uralensis and their application in the construction of an efficient UDP-recycling system. Journal of Agricultural and Food Chemistry, 2019, 67(42): 11694-11702.
11. Qiaofeng Li, Tian Jiang, Rui Liu, Xudong Feng*, Chun Li*. Tuning the pH profile of β-glucuronidase by rational site-directed mutagenesis for efficient transformation of glycyrrhizin. Applied Microbiology and Biotechnology, 2019, 103(12): 4813-4823.
12. Beijia Han, Yuhui Hou, Tian Jiang, Bo Lv, Lina Zhao, Xudong Feng*, Chun Li*. Computation-aided rational deletion of C-terminal region improved the stability, activity, and expression level of GH2 β-glucuronidase. Journal of Agricultural and Food Chemistry, 2018, 66(43): 11380-11389.
13. Yujia Zhao, Jingjing Fan, Chen Wang, Xudong Feng*, Chun Li*. Enhancing oleanolic acid production in engineered Saccharomyces cerevisiae. Bioresource Technology, 2018, 257: 339-343.