Research output per year
Research output per year
Personal profile
Personal profile
霍毅欣*, 基于学科交叉实施生命科学基础类课程教学改革, 生物工程学报, 2023, 39(11): 4718-4729.
11. Fajin Li, Jianhuo Fang, Yifan Yu, Sijia Hao, Qin Zou, Qinglin Zeng and Xuerui Yang*. Reanalysis of ribosome profiling datasets reveals a function of rocaglamide A in perturbing the dynamics of translation elongation via eIF4A. Nature Communications. 2023, 14, 553. (SCI, IF=17.694, Q1, TOP)
10. Changgeng Xu, Qin Zou, Jiheng Tian, Mengyuan Li, Baowen Xing, Julia Gong, Jiangyun Wang, Yi-Xin Huo, and Shuyuan Guo. Simplified Construction of Engineered Bacillus subtilis Host for Improved Expression of Proteins Harboring Noncanonical Amino Acids. ACS Synthetic Biology. 2023, 12(2):583-595. (SCI, IF=5.249, Q1, TOP)
9. Xiaolin Hu#, Qin Zou#, Li Yao, Xuerui Yang*. Survey of the binding preferences of RNA-binding proteins to RNA editing events. Genome Biology. 2022, 23(1):169. (SCI, IF=17.906, Q1, TOP) （#共一）
8. Yuting Wang#, Qin Zou#, Fajin Li, Wenwei Zhao, Hui Xu, Wenhao Zhang, Haiteng Deng, Xuerui Yang*. Identification of the cross-strand chimeric RNAs generated by fusions of bi-directional transcripts. Nature Communications. 2021, 12(1):4645. (SCI, IF=17.694, Q1, TOP)
7. Fang Xu#, Wanqing Du#, Qin Zou#, Yuting Wang#, Xin Zhang, Xudong Xing, Ying Li, Dachuan Zhang, Huimin Wang, Wenhao Zhang, Xinyao Hu, Xin Liu, Xiaoling Liu, Shaojin Zhang, Jinqiang Yu, Jianhuo Fang, Fajin Li, Ying Zhou, Tieqiang Yue, Na Mi, Haiteng Deng, Peng Zou, Xiaowei Chen, Xuerui Yang* and Li Yu*. COPII mitigates ER stress by promoting formation of ER whorls. Cell Research. 2021, 31(2):141-156. (SCI, IF=46.297, Q1, TOP)
6. Mingli Zhu#, Qin Zou#, Rongyao Huang, Ying Li, Xudon Xing, Jianhuo Fang, Liang Ma, Lifei Li, Xuerui Yang* and Li Yu*. Lateral transfer of mRNA by migrasomes modifies the recipient cell. Cell Research. 2021, 31(2):237-240. (SCI, IF=46.297, Q1, TOP)
5. Qin Zou, Zhengtao Xiao, Rongyao Huang, Xin Wang, Xun Wang, Haitao Zhao, and Xuerui Yang*. Survey of the translation shifts in hepatocellular carcinoma with ribosome profiling. Theranostics. 2019, 9(14):4141-4155. (SCI, IF=12.400, Q1, TOP)
4. Yusheng Wu#, Wenwei Zhao#, Yang Liu#, Xiangtian Tan, Xin Li, Qin Zou, Zhengtao Xiao, Hui Xu, Yuting Wang, Xuerui Yang*. Function of HNRNPC in breast cancer cells by controlling the dsRNA-induced interferon response. The EMBO Journal. 2018, 37(23):e99017. (SCI, IF=14.012, Q1, TOP)
3. Yanqing Zhang, Zhengtao Xiao, Qin Zou, Jianhuo Fang, Qifan Wang, Xuerui Yang* and Ning Gao*. Ribosome Profiling Reveals Genome-wide Cellular Translational Regulation upon Heat Stress in Escherichia coli. Genomics Proteomics Bioinformatics. 2017, 15(5):324-330. (SCI, IF=6.409, Q1, TOP)
2. Zhen Lin, Phillip J Hsu, Xudong Xing, Jianhuo Fang, Zhike Lu, Qin Zou, Kejia Zhang, Xiao Zhang, Yuchuan Zhou, Teng Zhang, Youcheng Zhang, Wanlu Song, Guifang Jia, Xuerui Yang*, Chuan He* and Ming-Han Tong*. Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis. Cell Research. 2017, 27(10):1216-1230. (SCI, IF=46.297, Q1, TOP)
1. Zhengtao Xiao, Qin Zou, Yu Liu and Xuerui Yang*. Genome-wide assessment of differential translations with ribosome profiling data. Nature Communications. 2016, 7:11194. (SCI, IF=17.694, Q1, TOP)
申请专利
1. 一种适用于检测病原体的方法
主讲课程
1. 生命科学基础A（本科生专业课程）
2. 医用生物技术（本科生专业课程）
3. 核酸检测的流程解析及实操（开放课程）
4. 生物医学数据分析可视化（开放课程）
霍毅欣*, 基于学科交叉实施生命科学基础类课程教学改革, 生物工程学报, 2023, 39(11): 4718-4729.
11. Fajin Li, Jianhuo Fang, Yifan Yu, Sijia Hao, Qin Zou, Qinglin Zeng and Xuerui Yang*. Reanalysis of ribosome profiling datasets reveals a function of rocaglamide A in perturbing the dynamics of translation elongation via eIF4A. Nature Communications. 2023, 14, 553. (SCI, IF=17.694, Q1, TOP)
10. Changgeng Xu, Qin Zou, Jiheng Tian, Mengyuan Li, Baowen Xing, Julia Gong, Jiangyun Wang, Yi-Xin Huo, and Shuyuan Guo. Simplified Construction of Engineered Bacillus subtilis Host for Improved Expression of Proteins Harboring Noncanonical Amino Acids. ACS Synthetic Biology. 2023, 12(2):583-595. (SCI, IF=5.249, Q1, TOP)
9. Xiaolin Hu#, Qin Zou#, Li Yao, Xuerui Yang*. Survey of the binding preferences of RNA-binding proteins to RNA editing events. Genome Biology. 2022, 23(1):169. (SCI, IF=17.906, Q1, TOP) （#共一）
8. Yuting Wang#, Qin Zou#, Fajin Li, Wenwei Zhao, Hui Xu, Wenhao Zhang, Haiteng Deng, Xuerui Yang*. Identification of the cross-strand chimeric RNAs generated by fusions of bi-directional transcripts. Nature Communications. 2021, 12(1):4645. (SCI, IF=17.694, Q1, TOP)
7. Fang Xu#, Wanqing Du#, Qin Zou#, Yuting Wang#, Xin Zhang, Xudong Xing, Ying Li, Dachuan Zhang, Huimin Wang, Wenhao Zhang, Xinyao Hu, Xin Liu, Xiaoling Liu, Shaojin Zhang, Jinqiang Yu, Jianhuo Fang, Fajin Li, Ying Zhou, Tieqiang Yue, Na Mi, Haiteng Deng, Peng Zou, Xiaowei Chen, Xuerui Yang* and Li Yu*. COPII mitigates ER stress by promoting formation of ER whorls. Cell Research. 2021, 31(2):141-156. (SCI, IF=46.297, Q1, TOP)
6. Mingli Zhu#, Qin Zou#, Rongyao Huang, Ying Li, Xudon Xing, Jianhuo Fang, Liang Ma, Lifei Li, Xuerui Yang* and Li Yu*. Lateral transfer of mRNA by migrasomes modifies the recipient cell. Cell Research. 2021, 31(2):237-240. (SCI, IF=46.297, Q1, TOP)
5. Qin Zou, Zhengtao Xiao, Rongyao Huang, Xin Wang, Xun Wang, Haitao Zhao, and Xuerui Yang*. Survey of the translation shifts in hepatocellular carcinoma with ribosome profiling. Theranostics. 2019, 9(14):4141-4155. (SCI, IF=12.400, Q1, TOP)
4. Yusheng Wu#, Wenwei Zhao#, Yang Liu#, Xiangtian Tan, Xin Li, Qin Zou, Zhengtao Xiao, Hui Xu, Yuting Wang, Xuerui Yang*. Function of HNRNPC in breast cancer cells by controlling the dsRNA-induced interferon response. The EMBO Journal. 2018, 37(23):e99017. (SCI, IF=14.012, Q1, TOP)
3. Yanqing Zhang, Zhengtao Xiao, Qin Zou, Jianhuo Fang, Qifan Wang, Xuerui Yang* and Ning Gao*. Ribosome Profiling Reveals Genome-wide Cellular Translational Regulation upon Heat Stress in Escherichia coli. Genomics Proteomics Bioinformatics. 2017, 15(5):324-330. (SCI, IF=6.409, Q1, TOP)
2. Zhen Lin, Phillip J Hsu, Xudong Xing, Jianhuo Fang, Zhike Lu, Qin Zou, Kejia Zhang, Xiao Zhang, Yuchuan Zhou, Teng Zhang, Youcheng Zhang, Wanlu Song, Guifang Jia, Xuerui Yang*, Chuan He* and Ming-Han Tong*. Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis. Cell Research. 2017, 27(10):1216-1230. (SCI, IF=46.297, Q1, TOP)
1. Zhengtao Xiao, Qin Zou, Yu Liu and Xuerui Yang*. Genome-wide assessment of differential translations with ribosome profiling data. Nature Communications. 2016, 7:11194. (SCI, IF=17.694, Q1, TOP)
申请专利
1. 一种适用于检测病原体的方法
主讲课程
1. 生命科学基础A（本科生专业课程）
2. 医用生物技术（本科生专业课程）
3. 核酸检测的流程解析及实操（开放课程）
4. 生物医学数据分析可视化（开放课程）
Research Interests
His research focuses on translomics, protein translation regulatory networks and translation mechanisms. Through the integrated analysis of multi-omics big data, the regulatory factors of translation are systematically identified from multiple perspectives, and the regulatory pathways of translation process are explored, so as to build a translation regulatory network.
The details include:
1. Systematic Studies on translation omics and Translation Regulation
2. Systematic Study on transcriptome and translation group of high-yielding strains
3. Engineered bacteria in gene therapy and cell therapy of diseases and tumors
His research focuses on translomics, protein translation regulatory networks and translation mechanisms. Through the integrated analysis of multi-omics big data, the regulatory factors of translation are systematically identified from multiple perspectives, and the regulatory pathways of translation process are explored, so as to build a translation regulatory network.
The details include:
1. Systematic Studies on translation omics and Translation Regulation
2. Systematic Study on transcriptome and translation group of high-yielding strains
3. Engineered bacteria in gene therapy and cell therapy of diseases and tumors
Education
2022.01-present Assistant Professor, Special Associate Researcher, Master's Supervisor, School of Life Science, Beijing Institute of Technology 2020.01-2021.12 Post-Doctoral Supervisor, School of Life Sciences, Tsinghua University: Yang Xuerui
2012.09-2019.12 School of Life Sciences, Tsinghua University Doctor of Science Supervisor: Yang Xuerui
2008.09-2012.07 College of Life Science and Technology, Huazhong Agricultural University, B.S. Supervisor: Wang Xiaodong (Beijing Institute of Life Sciences)
Professional Experience
2022.01-present Assistant Professor, Special Associate Researcher, Master's Supervisor, School of Life Science, Beijing Institute of Technology 2020.01-2021.12 Post-Doctoral Supervisor, School of Life Sciences, Tsinghua University: Yang Xuerui
2012.09-2019.12 School of Life Sciences, Tsinghua University Doctor of Science Supervisor: Yang Xuerui
2008.09-2012.07 College of Life Science and Technology, Huazhong Agricultural University, B.S. Supervisor: Wang Xiaodong (Beijing Institute of Life Sciences)
2022.01-present Assistant Professor, Special Associate Researcher, Master's Supervisor, School of Life Science, Beijing Institute of Technology 2020.01-2021.12 Post-Doctoral Supervisor, School of Life Sciences, Tsinghua University: Yang Xuerui
2012.09-2019.12 School of Life Sciences, Tsinghua University Doctor of Science Supervisor: Yang Xuerui
2008.09-2012.07 College of Life Science and Technology, Huazhong Agricultural University, B.S. Supervisor: Wang Xiaodong (Beijing Institute of Life Sciences)
Research Achievement
1. Hebei Natural Science Foundation Project, 2023/01-2025/12, Director
2. Beijing Institute of Technology "Young Teachers Academic Program", 2022-01-2024/12, Host
3. Tsinghua Excellent Postdoctoral Foundation, Tsinghua University-Peking University Life Sciences Joint Center, Host
4. Project of National Natural Science Foundation of China, high-precision systematic analysis of anomalies in translation group of liver Cancer and colorectal cancer tumors, 2020/01-2023/12,660,000, participated in
5. National Key R&D Program "Precision Medicine Research", Cross-biometrics research and biomedical big data analysis of colorectal cancer clinical samples, 2016/07-2020/122.95 million, participated in
6. National Natural Science Major Research Program, Systematic study on identification and regulation of tissue-specific lncRNA/mRNA Heterotypic transcription gene pairs in mice, 2016/01-2018/121.02 million, participated in
7. Tsinghua University Independent Research Program, Systematic Identification and Analysis of Novel Heterostrand Chimeric RNA, 2019/07-2020/06, 400,000, completed
8. Independent Research Program of Tsinghua University, Systematic Study on the endogenesis and functional Mechanism of Hepatocellular carcinoma tumor tissues, 2015/03-2017/12,500,000, completed
9. Independent Research Program of Tsinghua University, Stress Regulation Mechanism of Ribosomal protein Translation Process, 2014/01-2016/125,900, completed
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Reanalysis of ribosome profiling datasets reveals a function of rocaglamide A in perturbing the dynamics of translation elongation via eIF4A
Li, F., Fang, J., Yu, Y., Hao, S., Zou, Q., Zeng, Q. & Yang, X., Dec 2023, In: Nature Communications. 14, 1, 553.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Simplified Construction of Engineered Bacillus subtilis Host for Improved Expression of Proteins Harboring Noncanonical Amino Acids
Xu, C., Zou, Q., Tian, J., Li, M., Xing, B., Gong, J., Wang, J., Huo, Y. X. & Guo, S., 17 Feb 2023, In: ACS Synthetic Biology. 12, 2, p. 583-595 13 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
基于学科交叉实施生命科学基础类课程教学改革
Translated title of the contribution :Interdisciplinary teaching-assisted education reform in “Principal Biology” Research output: Contribution to journal › Article › peer-review
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Survey of the binding preferences of RNA-binding proteins to RNA editing events
Hu, X., Zou, Q., Yao, L. & Yang, X., Dec 2022, In: Genome Biology. 23, 1, 169.Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus) -
COPII mitigates ER stress by promoting formation of ER whorls
Xu, F., Du, W., Zou, Q., Wang, Y., Zhang, X., Xing, X., Li, Y., Zhang, D., Wang, H., Zhang, W., Hu, X., Liu, X., Liu, X., Zhang, S., Yu, J., Fang, J., Li, F., Zhou, Y., Yue, T. & Mi, N. & 5 others, , Feb 2021, In: Cell Research. 31, 2, p. 141-156 16 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Citations (Scopus)