Abstract
2-(2-Benzyloxycarbonylaminothiazol-4-yl)-5-(3-methyl-2-butenyloxycarbonyl) pent-2-enoic acid (1), the key intermediate of ceftibuten, was prepared from methyl (2-aminothiazol-4-yl)acetate which could be easily bought in China through a three-step reaction of amino group protection, Michael addition-elimination and selective esterification with an overall yield of 63.0%. This facile and lower-cost process was suitable for industrial production.
| Original language | English |
|---|---|
| Pages (from-to) | 604-607+635 |
| Journal | Chinese Journal of Antibiotics |
| Volume | 32 |
| Issue number | 10 |
| Publication status | Published - 2007 |
Keywords
- 2-(2-Benzyloxycarbonylaminothiazol-4-yl)-5-(3-methyl-2-butenyloxycarbonyl) pent-2-enoic acid
- Ceftibuten
- Intermediate
- Synthesis