TY - JOUR
T1 - Regional Homogeneity within the Default Mode Network in Bipolar Depression
T2 - A Resting-State Functional Magnetic Resonance Imaging Study
AU - Liu, Chun Hong
AU - Ma, Xin
AU - Li, Feng
AU - Wang, Yong Jun
AU - Tie, Chang Le
AU - Li, Su Fang
AU - Chen, Tao Lin
AU - Fan, Ting ting
AU - Zhang, Yu
AU - Dong, Jie
AU - Yao, Li
AU - Wu, Xia
AU - Wang, Chuan Yue
PY - 2012/11/2
Y1 - 2012/11/2
N2 - Aim: We sought to use a regional homogeneity (ReHo) approach as an index in resting-state functional magnetic resonance imaging (fMRI) to investigate the features of spontaneous brain activity within the default mode network (DMN) in patients suffering from bipolar depression (BD). Methods: Twenty-six patients with BD and 26 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans. We compared the differences in ReHo between the two groups within the DMN and investigated the relationships between sex, age, years of education, disease duration, the Hamilton Rating Scale for Depression (HAMD) total score, and ReHo in regions with significant group differences. Results: Our results revealed that bipolar depressed patients had increased ReHo in the left medial frontal gyrus and left inferior parietal lobe compared to healthy controls. No correlations were found between regional ReHo values and sex, age, and clinical features within the BD group. Conclusions: Our findings indicate that abnormal brain activity is mainly distributed within prefrontal-limbic circuits, which are believed to be involved in the pathophysiological mechanisms underlying bipolar depression.
AB - Aim: We sought to use a regional homogeneity (ReHo) approach as an index in resting-state functional magnetic resonance imaging (fMRI) to investigate the features of spontaneous brain activity within the default mode network (DMN) in patients suffering from bipolar depression (BD). Methods: Twenty-six patients with BD and 26 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans. We compared the differences in ReHo between the two groups within the DMN and investigated the relationships between sex, age, years of education, disease duration, the Hamilton Rating Scale for Depression (HAMD) total score, and ReHo in regions with significant group differences. Results: Our results revealed that bipolar depressed patients had increased ReHo in the left medial frontal gyrus and left inferior parietal lobe compared to healthy controls. No correlations were found between regional ReHo values and sex, age, and clinical features within the BD group. Conclusions: Our findings indicate that abnormal brain activity is mainly distributed within prefrontal-limbic circuits, which are believed to be involved in the pathophysiological mechanisms underlying bipolar depression.
UR - http://www.scopus.com/inward/record.url?scp=84868322380&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0048181
DO - 10.1371/journal.pone.0048181
M3 - Article
C2 - 23133615
AN - SCOPUS:84868322380
SN - 1932-6203
VL - 7
JO - PLoS ONE
JF - PLoS ONE
IS - 11
M1 - e48181
ER -