Nano-herb medicine and PDT induced synergistic immunotherapy for colon cancer treatment

Xiaoli Wu; Han Yang; Xingmeng Chen; Junxiao Gao; Yue Duan; Daohe Wei; Jinchao Zhang; Kun Ge; Xing Jie Liang; Yuanyu Huang; Sizhou Feng; Rongli Zhang; Xi Chen; Jin Chang

doi:10.1016/j.biomaterials.2021.120654

Nano-herb medicine and PDT induced synergistic immunotherapy for colon cancer treatment

Xiaoli Wu, Han Yang, Xingmeng Chen, Junxiao Gao, Yue Duan, Daohe Wei, Jinchao Zhang, Kun Ge, Xing Jie Liang, Yuanyu Huang, Sizhou Feng, Rongli Zhang, Xi Chen^*, Jin Chang^*

^*Corresponding author for this work

Advanced Research Institute of Multidisciplinary Science

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

A variety of therapies have been developed and used for the treatment of colon cancer, however, the high mortality rate remains high and more effective strategies are still in urgent needs. In this study, an immunotherapy approach that is composed of innate immune activator Astragaloside III (As) and the photodynamic therapy (PDT) reagent chlorine e6 (Ce6) ((As + Ce6)@MSNs-PEG), was developed for colon cancer treatment. We showed that (As + Ce6)@MSNs-PEG could effectively activate NK cells and inhibit the proliferation of tumor cells in vitro. It could also effectively reach tumor sites, induce infiltration of immune cells into the tumor, and enhance the cytotoxicity of natural killer cells and CD8⁺ T cells in vivo. Without obvious side effects, (As + Ce6)@MSNs-PEG treatment significantly inhibited tumor growth and extended the lifespan of tumor-bearing mice. Further results revealed that treatment of (As + Ce6)@MSNs-PEG led to enhanced IFN secretion by immune cells and increased T-box transcription factor (T-bet), which is highly expressed by T cells. Therefore, (As + Ce6)@MSNs-PEG may serve as an effective and safe platform for combinatory use with nano-herb medicine and PDT to provide a new therapy for colon cancer treatment.

Original language	English
Article number	120654
Journal	Biomaterials
Volume	269
DOIs	https://doi.org/10.1016/j.biomaterials.2021.120654
Publication status	Published - Feb 2021

Keywords

Astragaloside III
Chlorine e6
Mesoporous silica nanoparticles
NK cells
Synergistic immunotherapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2021.120654

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title = "Nano-herb medicine and PDT induced synergistic immunotherapy for colon cancer treatment",

abstract = "A variety of therapies have been developed and used for the treatment of colon cancer, however, the high mortality rate remains high and more effective strategies are still in urgent needs. In this study, an immunotherapy approach that is composed of innate immune activator Astragaloside III (As) and the photodynamic therapy (PDT) reagent chlorine e6 (Ce6) ((As + Ce6)@MSNs-PEG), was developed for colon cancer treatment. We showed that (As + Ce6)@MSNs-PEG could effectively activate NK cells and inhibit the proliferation of tumor cells in vitro. It could also effectively reach tumor sites, induce infiltration of immune cells into the tumor, and enhance the cytotoxicity of natural killer cells and CD8+ T cells in vivo. Without obvious side effects, (As + Ce6)@MSNs-PEG treatment significantly inhibited tumor growth and extended the lifespan of tumor-bearing mice. Further results revealed that treatment of (As + Ce6)@MSNs-PEG led to enhanced IFN secretion by immune cells and increased T-box transcription factor (T-bet), which is highly expressed by T cells. Therefore, (As + Ce6)@MSNs-PEG may serve as an effective and safe platform for combinatory use with nano-herb medicine and PDT to provide a new therapy for colon cancer treatment.",

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author = "Xiaoli Wu and Han Yang and Xingmeng Chen and Junxiao Gao and Yue Duan and Daohe Wei and Jinchao Zhang and Kun Ge and Liang, {Xing Jie} and Yuanyu Huang and Sizhou Feng and Rongli Zhang and Xi Chen and Jin Chang",

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T1 - Nano-herb medicine and PDT induced synergistic immunotherapy for colon cancer treatment

AU - Wu, Xiaoli

AU - Yang, Han

AU - Chen, Xingmeng

AU - Gao, Junxiao

AU - Duan, Yue

AU - Wei, Daohe

AU - Zhang, Jinchao

AU - Ge, Kun

AU - Liang, Xing Jie

AU - Huang, Yuanyu

AU - Feng, Sizhou

AU - Zhang, Rongli

AU - Chen, Xi

AU - Chang, Jin

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AB - A variety of therapies have been developed and used for the treatment of colon cancer, however, the high mortality rate remains high and more effective strategies are still in urgent needs. In this study, an immunotherapy approach that is composed of innate immune activator Astragaloside III (As) and the photodynamic therapy (PDT) reagent chlorine e6 (Ce6) ((As + Ce6)@MSNs-PEG), was developed for colon cancer treatment. We showed that (As + Ce6)@MSNs-PEG could effectively activate NK cells and inhibit the proliferation of tumor cells in vitro. It could also effectively reach tumor sites, induce infiltration of immune cells into the tumor, and enhance the cytotoxicity of natural killer cells and CD8+ T cells in vivo. Without obvious side effects, (As + Ce6)@MSNs-PEG treatment significantly inhibited tumor growth and extended the lifespan of tumor-bearing mice. Further results revealed that treatment of (As + Ce6)@MSNs-PEG led to enhanced IFN secretion by immune cells and increased T-box transcription factor (T-bet), which is highly expressed by T cells. Therefore, (As + Ce6)@MSNs-PEG may serve as an effective and safe platform for combinatory use with nano-herb medicine and PDT to provide a new therapy for colon cancer treatment.

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Nano-herb medicine and PDT induced synergistic immunotherapy for colon cancer treatment

Abstract

Keywords

UN SDGs

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