Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates

Hai Hua Lu; Xu Fan Wang; Chang Jiang Yao; Jian Ming Zhang; Hong Wu; Wen Jing Xiao

doi:10.1039/b905033g

Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates

Hai Hua Lu^*, Xu Fan Wang, Chang Jiang Yao, Jian Ming Zhang, Hong Wu, Wen Jing Xiao

^*Corresponding author for this work

Central China Normal University

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

A useful Michael addition reaction using nitroalkanes as the nucleophile and 4-oxo-enoates as the Michael acceptor has been disclosed, and the reaction allows expedient access to functionalized chiral γ-keto esters in high yields and excellent enantioselectivities (up to 98% ee), with a low catalyst loading.

Original language	English
Pages (from-to)	4251-4253
Number of pages	3
Journal	Chemical Communications
Issue number	28
DOIs	https://doi.org/10.1039/b905033g
Publication status	Published - 2009
Externally published	Yes

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title = "Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates",

abstract = "A useful Michael addition reaction using nitroalkanes as the nucleophile and 4-oxo-enoates as the Michael acceptor has been disclosed, and the reaction allows expedient access to functionalized chiral γ-keto esters in high yields and excellent enantioselectivities (up to 98% ee), with a low catalyst loading.",

author = "Lu, {Hai Hua} and Wang, {Xu Fan} and Yao, {Chang Jiang} and Zhang, {Jian Ming} and Hong Wu and Xiao, {Wen Jing}",

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doi = "10.1039/b905033g",

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T1 - Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates

AU - Lu, Hai Hua

AU - Wang, Xu Fan

AU - Yao, Chang Jiang

AU - Zhang, Jian Ming

AU - Wu, Hong

AU - Xiao, Wen Jing

PY - 2009

Y1 - 2009

N2 - A useful Michael addition reaction using nitroalkanes as the nucleophile and 4-oxo-enoates as the Michael acceptor has been disclosed, and the reaction allows expedient access to functionalized chiral γ-keto esters in high yields and excellent enantioselectivities (up to 98% ee), with a low catalyst loading.

AB - A useful Michael addition reaction using nitroalkanes as the nucleophile and 4-oxo-enoates as the Michael acceptor has been disclosed, and the reaction allows expedient access to functionalized chiral γ-keto esters in high yields and excellent enantioselectivities (up to 98% ee), with a low catalyst loading.

UR - http://www.scopus.com/inward/record.url?scp=67650422264&partnerID=8YFLogxK

U2 - 10.1039/b905033g

DO - 10.1039/b905033g

M3 - Article

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AN - SCOPUS:67650422264

SN - 1359-7345

SP - 4251

EP - 4253

JO - Chemical Communications

JF - Chemical Communications

IS - 28

ER -

Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates

Abstract

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