Electrospinning of synthesized triblock copolymers of ε-caprolactone and L-lactide for the application of vascular tissue engineering

Rong Xin Qiu, Chun Min Li, Lin Ye, Jian De Dong, Ai Ying Zhang, Yong Quan Gu, Zeng Guo Feng*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Biodegradable triblock copolymers of ε-caprolactone and L-lactide with varying compositions and molecular weights have been synthesized. They were then used to fabricate compliant small-diameter tissue engineered vascular scaffolds by using an electrospinning technique. The in vitro and in vivo degradation of the ultrafine fabrics was monitored to be faster than their counterpart cast films. A favorable interaction between the scaffolds and the mouse fibroblast L929 cells was demonstrated via MTT assay. A confluent, adherent monolayer of canine mesenchymal stem cells was observed in the tubular scaffold lumen after culture in a bioreactor for 3 days. The scaffold mechanical strength was strong enough to be transplanted into the canine carotid artery.

Original languageEnglish
Article number044105
JournalBiomedical Materials (Bristol)
Volume4
Issue number4
DOIs
Publication statusPublished - 2009

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