Dual Fenton Catalytic Nanoreactor for Integrative Type-I and Type-II Photodynamic Therapy against Hypoxic Cancer Cells

Xiao Cui; Jinfeng Zhang; Yingpeng Wan; F. Fang; Rui Chen; Dong Shen; Zhongming Huang; Shuang Tian; Yafang Xiao; Xiaozhen Li; Jipsa Chelora; Yanhong Liu; Wenjun Zhang; Chun Sing Lee

doi:10.1021/acsabm.9b00456

Dual Fenton Catalytic Nanoreactor for Integrative Type-I and Type-II Photodynamic Therapy against Hypoxic Cancer Cells

Xiao Cui, Jinfeng Zhang^*, Yingpeng Wan, F. Fang, Rui Chen, Dong Shen, Zhongming Huang, Shuang Tian, Yafang Xiao, Xiaozhen Li, Jipsa Chelora, Yanhong Liu, Wenjun Zhang, Chun Sing Lee

^*Corresponding author for this work

School of Life Science

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Tumor hypoxia is a noteworthy impediment to effective photodynamic therapy (PDT), as it would sharply weaken the effectiveness of oxygen-dependent PDT. To enable effective PDT in both hypoxia as well as normoxia circumstances, here, we report a multifunctional nanoreactor (C₃N₄/MnO₂ NPs), which guarantees effective type-II PDT (oxygen-dependent) in hypoxia by in situ oxygen generation via the Fenton reaction. In addition, the C₃N₄/MnO₂ NPs can also be used for oxygen-independent type-I PDT by evolving the cytotoxic hydroxyl radical to reduce reliance on intracellular oxygen content. In vitro cytotoxicity assays made evident that the C₃N₄/MnO₂ NPs exhibit a much higher cancer-cell-killing ability than C₃N₄ NPs not only in normoxia but also in hypoxic circumstances. The smart integration of type-I and type-II PDT into the therapeutic nanoplatform enables effective PDT even though intracellular oxygen is not satisfactory.

Original language	English
Pages (from-to)	3854-3860
Number of pages	7
Journal	ACS Applied Bio Materials
Volume	2
Issue number	9
DOIs	https://doi.org/10.1021/acsabm.9b00456
Publication status	Published - 16 Sept 2019

Keywords

CN
Fenton reaction
MnO
hypoxia
photodynamic therapy
type-I or type-II PDT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsabm.9b00456

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title = "Dual Fenton Catalytic Nanoreactor for Integrative Type-I and Type-II Photodynamic Therapy against Hypoxic Cancer Cells",

abstract = "Tumor hypoxia is a noteworthy impediment to effective photodynamic therapy (PDT), as it would sharply weaken the effectiveness of oxygen-dependent PDT. To enable effective PDT in both hypoxia as well as normoxia circumstances, here, we report a multifunctional nanoreactor (C3N4/MnO2 NPs), which guarantees effective type-II PDT (oxygen-dependent) in hypoxia by in situ oxygen generation via the Fenton reaction. In addition, the C3N4/MnO2 NPs can also be used for oxygen-independent type-I PDT by evolving the cytotoxic hydroxyl radical to reduce reliance on intracellular oxygen content. In vitro cytotoxicity assays made evident that the C3N4/MnO2 NPs exhibit a much higher cancer-cell-killing ability than C3N4 NPs not only in normoxia but also in hypoxic circumstances. The smart integration of type-I and type-II PDT into the therapeutic nanoplatform enables effective PDT even though intracellular oxygen is not satisfactory.",

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author = "Xiao Cui and Jinfeng Zhang and Yingpeng Wan and F. Fang and Rui Chen and Dong Shen and Zhongming Huang and Shuang Tian and Yafang Xiao and Xiaozhen Li and Jipsa Chelora and Yanhong Liu and Wenjun Zhang and Lee, {Chun Sing}",

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T1 - Dual Fenton Catalytic Nanoreactor for Integrative Type-I and Type-II Photodynamic Therapy against Hypoxic Cancer Cells

AU - Cui, Xiao

AU - Zhang, Jinfeng

AU - Wan, Yingpeng

AU - Fang, F.

AU - Chen, Rui

AU - Shen, Dong

AU - Huang, Zhongming

AU - Tian, Shuang

AU - Xiao, Yafang

AU - Li, Xiaozhen

AU - Chelora, Jipsa

AU - Liu, Yanhong

AU - Zhang, Wenjun

AU - Lee, Chun Sing

PY - 2019/9/16

Y1 - 2019/9/16

N2 - Tumor hypoxia is a noteworthy impediment to effective photodynamic therapy (PDT), as it would sharply weaken the effectiveness of oxygen-dependent PDT. To enable effective PDT in both hypoxia as well as normoxia circumstances, here, we report a multifunctional nanoreactor (C3N4/MnO2 NPs), which guarantees effective type-II PDT (oxygen-dependent) in hypoxia by in situ oxygen generation via the Fenton reaction. In addition, the C3N4/MnO2 NPs can also be used for oxygen-independent type-I PDT by evolving the cytotoxic hydroxyl radical to reduce reliance on intracellular oxygen content. In vitro cytotoxicity assays made evident that the C3N4/MnO2 NPs exhibit a much higher cancer-cell-killing ability than C3N4 NPs not only in normoxia but also in hypoxic circumstances. The smart integration of type-I and type-II PDT into the therapeutic nanoplatform enables effective PDT even though intracellular oxygen is not satisfactory.

AB - Tumor hypoxia is a noteworthy impediment to effective photodynamic therapy (PDT), as it would sharply weaken the effectiveness of oxygen-dependent PDT. To enable effective PDT in both hypoxia as well as normoxia circumstances, here, we report a multifunctional nanoreactor (C3N4/MnO2 NPs), which guarantees effective type-II PDT (oxygen-dependent) in hypoxia by in situ oxygen generation via the Fenton reaction. In addition, the C3N4/MnO2 NPs can also be used for oxygen-independent type-I PDT by evolving the cytotoxic hydroxyl radical to reduce reliance on intracellular oxygen content. In vitro cytotoxicity assays made evident that the C3N4/MnO2 NPs exhibit a much higher cancer-cell-killing ability than C3N4 NPs not only in normoxia but also in hypoxic circumstances. The smart integration of type-I and type-II PDT into the therapeutic nanoplatform enables effective PDT even though intracellular oxygen is not satisfactory.

KW - CN

KW - Fenton reaction

KW - MnO

KW - hypoxia

KW - photodynamic therapy

KW - type-I or type-II PDT

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ER -

Dual Fenton Catalytic Nanoreactor for Integrative Type-I and Type-II Photodynamic Therapy against Hypoxic Cancer Cells

Abstract

Keywords

UN SDGs

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