Cross-frequency transfer entropy characterize coupling of interacting nonlinear oscillators in complex systems

The purpose of this study is to introduce a method in quantifying cross-frequency information transfer to characterize directional couplers between irregular oscillations in complex systems. Importantly, the method should be able to reflect the intrinsic mechanism of interacting oscillations faithfully. Six types of interacting oscillators, including phase-amplitude, amplitude-amplitude, and component-amplitude cross-frequency transfer entropy as well as their inverse transfer entropies, are within our scope in untangling the brain connectivity. Challenges with nonlinear and nonstationary patterns are designed to validate the robustness of the proposed method. We suggest this approach could be effective in identifying driving and responding elements of interacting oscillators across different time scales. Meanwhile, an atlas of interacting oscillators in sleep is constructed. High-frequency amplitude can inversely drive low-frequency phase stronger than the standard phase-amplitude coupling, and the low-frequency amplitude can be the driving force to the high-frequency amplitude in addition to the low-frequency phase. Unlike the standard phase-amplitude coupling, the proposed cross-frequency transfer entropy is applicable to quantify the interactions across phases, amplitudes, or even the components without methodological adjustments. Meanwhile, the exploration of causal relationship enables the identification of the driving force of information flow.