基于反奖赏系统探究药物成瘾的神经调控机制

Drug addiction is a type of chronic recurrent brain disease with extremely complicated pathogenesis, which is often manifested as spontaneous and compulsive drug seeking and using behavior. The anti-reward system plays an extremely important role in the occurrence and development of drug addiction-related symptoms. This article provides a brief overview of the formation process, symptom representation, neural mechanism and motivational/behavioral changes of drug addiction and their adversarial process theory, as well as the anatomical structure of the anti-reward system and evidence for its involvement in regulating the occurrence and development of drug addiction. This work helps better understand the neural mechanism of drug addiction through the view of anti-reward system and provides insights for the treatment of related diseases and drug abuse.